The impact of surgical and percutaneous coronary revascularization on the cardiac myocyte

World Journal of Surgery
Kamal R Khabbaz, Sidney Levitsky

Abstract

Re-establishing coronary blood flow to a segment of myocardium suffering from cessation or diminution of flow, either with surgical or percutaneous approaches, may be complicated by injury to the myocardium. During surgical revascularization with coronary artery bypass grafting (CABG), aortic cross-clamping and subsequent reduction in oxygen transport to the myocardium may result in cardiac myocyte injury and myonecrosis. This injury can be compounded if protection of the myocardium using myocardial protective strategies is not adequate. Ischemia/reperfusion cellular alterations may contribute to this injury as well. Percutaneous coronary interventions (PCI) are also associated with myonecrosis resulting from side branch compromise, distal embolization of debris, and plugging of the microcirculation, as well as ischemia/reperfusion injury. Intracoronary filtering devices have not been shown to improve outcomes associated with such complications. Which revascularization strategy is associated with superior outcomes and less cardiac myocyte necrosis is an area of continuing controversy.

References

May 1, 1994·Journal of Cardiac Surgery·R A KlonerG L Kay
Jan 1, 1993·The Annals of Thoracic Surgery·P MenaschéA Piwnica
Jan 16, 2002·The Annals of Thoracic Surgery·K R KhabbazK G Warner
Oct 3, 2002·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jeffrey J PopmaEberhard Grube
Dec 12, 2002·Journal of the American College of Cardiology·Sorin J BrenerEric J Topol
Jul 2, 1955·Lancet·D G MELROSEJ B BAKER
Jan 29, 2005·The Journal of Thoracic and Cardiovascular Surgery·Shukri F KhuriWilliam G Henderson
May 27, 2005·The New England Journal of Medicine·Edward L HannanEric A Rose
May 27, 2005·The New England Journal of Medicine·Bernard J Gersh, Robert L Frye
May 26, 2006·Journal of Cardiothoracic Surgery·David P Taggart

❮ Previous
Next ❯

Citations

May 1, 2010·Transplantation Proceedings·W H HuangJ Wei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Pharmaceutical Design
G K GlantzounisD A Galaris
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Matthias ThielmannHeinz Jakob
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Vinod VenugopalDerek J Hausenloy
© 2021 Meta ULC. All rights reserved