The impact of tear film components on in vitro lipid uptake

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Holly LorentzLyndon Jones

Abstract

To analyze the influence of various tear film components on in vitro deposition of two lipids (cholesterol and phosphatidylcholine) on three contact lens materials. Etafilcon A, balafilcon A, and senofilcon A were incubated in four different incubation solutions for 3 or 14 days: an artificial tear solution containing lipids and proteins, a protein tear solution containing proteins and the lipid of interest, a lipid tear solution containing lipids and no proteins, and a single lipid tear solution containing the lipid of interest only. Each incubation solution contained one of the two radiolabeled lipids: C-cholesterol (C) or C-phosphatidylcholine (PC). After soaking, lenses were removed from the incubation solution, the lipids were extracted and quantified using a beta counter, and masses of lipid were calculated using standard calibration curves. This experiment examined several different parameters influencing lipid deposition on contact lenses, including lens material, length of incubation, and the composition of the incubation solution. Overall, lipid deposited differently on different lens materials (p < 0.0005), with the order of deposition most commonly being balafilcon > senofilcon > etafilcon. Incubation solution had a...Continue Reading

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Citations

Dec 29, 2012·Eye & Contact Lens·Lyndon Jones, Charles H Powell
Jun 8, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·William G PittEdmond Peter Maziarz
Apr 9, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Alan NgLyndon Jones
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May 31, 2017·Current Eye Research·Burkhardt S Schuett, Thomas J Millar
Jul 26, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Cécile MaissaJoseph W Boclair
Sep 10, 2013·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hendrik WaltherLyndon W Jones
Nov 20, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hendrik WaltherLyndon W Jones
Apr 24, 2014·Eye & Contact Lens·Madalena LiraManuel F M Costa
Oct 9, 2019·Journal of Biomaterials Science. Polymer Edition·Steven CheungLyndon Jones
Oct 20, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Holly LorentzLyndon Jones
Jun 14, 2014·Annals of Biomedical Engineering·Saman MohammadiMaud Gorbet
Aug 12, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Steven CheungLyndon W Jones
Oct 18, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Ngai Keung TamE Peter Maziarz
Sep 20, 2019·Translational Vision Science & Technology·Chau-Min PhanLyndo Jones
Jun 18, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Cheng-Chun PengClayton J Radke
May 30, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Negar Babaei OmaliLyndon Jones
Feb 14, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Micael AlvesMadalena Lira
Feb 27, 2020·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Anna Sulley, Kathy Dumbleton
Mar 7, 2021·Pharmaceutics·Chau-Minh PhanLyndon Jones
Apr 9, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hendrik WaltherLyndon W Jones

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