The impact of the CAG repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old Danish men: Odense Androgen Study

European Journal of Endocrinology
Torben Leo NielsenMarianne Andersen

Abstract

The number of CAG repeats (CAG(n)) within the CAG repeat polymorphism of the androgen receptor gene correlates inversely with the transactivation of the receptor. To examine the impact of CAG(n) on muscle, fat distribution, and circulating androgen levels. Design, settings and participants Population-based, cross-sectional study of 783 Danish men aged 20-29 years. Genotyping was performed in 767 men. Areas of thigh and lower trunk muscle (muscle(thigh) and muscle(lower trunk)), subcutaneous adipose tissues (SAT(thigh) and SAT(lower trunk)), and deep adipose tissues (i.m. and visceral) were measured in 393 men by magnetic resonance imaging (MRI). Lean body mass (LBM) and fat mass (FM) were measured in all men by whole body dual-energy X-ray absorptiometry (DEXA). The absolute areas acquired by MRI were the main outcomes. The absolute DEXA measurements and relative assessments of both modalities were considered as the secondary outcomes. Results CAG(n) (range: 10-32) correlated inversely with absolute muscle(thigh) (r=-0.108), absolute muscle(lower trunk) (r=-0.132), relative muscle(thigh) (r=-0.128), relative muscle(lower trunk) (r=-0.126), relative LBM(lower extremity) (r=-0.108), and relative LBM(total) (r=-0.082), and positiv...Continue Reading

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Citations

Jun 28, 2011·Human Genetics·Li-Jun TanHong-Wen Deng
Aug 11, 2011·Physiological Genomics·Ryan L SheppardStephen M Roth
Dec 23, 2011·European Journal of Endocrinology·L FrederiksenM Andersen
Oct 5, 2013·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·David L KendlerJohn Shepherd
Nov 13, 2014·The Journal of Sexual Medicine·Christian BuchliAnna Martling
Sep 17, 2015·Reviews in Endocrine & Metabolic Disorders·Eberhard Nieschlag, Elena Vorona
Oct 25, 2016·Scandinavian Journal of Medicine & Science in Sports·J G Ponce-GonzálezJ A L Calbet
Feb 16, 2012·Human Mutation·Bruce GottliebMark Trifiro
Oct 1, 2015·International Journal of Endocrinology·Giacomo TirabassiGiancarlo Balercia
Feb 11, 2011·Personality & Social Psychology Bulletin·Aaron W Lukaszewski, James R Roney
Feb 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Annette MouritsenAnders Juul

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