The impact of the CB2-63 polymorphism on the histological presentation of chronic hepatitis B

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
N CoppolaFrancesca Rossi

Abstract

The impact of the cannabinoid receptor 2 (CB2) rs35761398 polymorphism on chronic hepatitis B (CHB) was evaluated in 106 consecutive biopsy-proven CHB patients naive for antiviral therapy. A histological activity index (HAI) > 8 (Ishak scoring) was more frequent in patients with CB2-63 RR than in those with CB2-63 QR or QQ (37% vs. 16.7%, p < 0.05). The logistic regression analysis identified CB2-63 RR (p < 0.05) and a fibrosis score >3 (p < 0.005) as independently associated with an HAI >8. The observation that the CB2-63 RR variant is an independent predictor of extensive necroinflammation opens up new prospects in the study of CHB.

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Citations

Oct 25, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nicola CoppolaFrancesca Rossi
Mar 21, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Erhei DaiZhen Li
Jun 14, 2018·International Forum of Allergy & Rhinology·Alessia CorradoJoshua M Levy

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