The impact of the coronary sinus reducer upon left ventricular function in patients with refractory angina pectoris

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Georgios TzanisFrancesco Giannini

Abstract

To evaluate the impact of coronary sinus (CS) Reducer implantation upon left ventricular (LV) function. CS Reducer implantation is associated with symptomatic relief in patients with refractory angina. The effects of the device upon left ventricular function remains unknown. Prior to device implantation and at 4-months, resting ventricular volumes and function were measured using cardiac magnetic resonance (CMR). Stress CMR was performed to extract quantitative indices of myocardial perfusion (myocardial perfusion reserve index-MPRI). Nineteen patients (18 males, 66.0 [IQR 56.0-77.0] years), underwent successful Reducer implantation. Sixteen (84%) patients improved by at least 1 CCS class. Four months after Reducer implantation, we noticed a significant improvement in LV ejection fraction (LVEF) (61 [IQR 47-71] to 66 [IQR 57-72] %; p = .009), a reduction in LV end-diastolic volume (LVEDV)/Body surface area (BSA) (65.7 [IQR 57.4-89.6] to 64.7 [IQR 53.7-74.1] mL/m2 ; p = .036) and a reduction in LV end-systolic volume (LVESV)/BSA (28.7 [IQR 18.6-38.8] to 20.0 [IQR 15.0-31.4] mL/m2 ; p = .007). Patients with reduced EF (EF < 50%, n = 6) presented a greater increase of EF at follow up compared to patients with preserved EF (11.3 [I...Continue Reading

References

May 29, 1948·Journal of the American Medical Association·C S BECK, E STANTON
Feb 5, 2015·The New England Journal of Medicine·Stefan VerheyeShmuel Banai
Oct 12, 2017·European Heart Journal·Maayan KonigsteinShmuel Banai
Apr 21, 2018·JACC. Cardiovascular Interventions·Francesco GianniniAntonio Colombo
Apr 25, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Maayan KonigsteinShmuel Banai
Nov 19, 2018·JACC. Cardiovascular Interventions·Guglielmo GalloneFrancesco Giannini

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Citations

May 19, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·E Marc Jolicoeur, Timothy D Henry
Aug 23, 2020·Biomedicines·Kudrat Rakhimov, Tommaso Gori
Sep 29, 2020·Medical Devices : Evidence and Research·Michal StanakPiotr Szymanski
Dec 29, 2020·European Heart Journal·Allan DaviesThomas F Lüscher
Feb 25, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Carlo ZivelonghiStefan Verheye
Dec 16, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Stefan VerheyeMaayan Konigstein

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