The impact of the definition of biochemical recurrence following salvage radiotherapy on outcomes and prognostication in patients with recurrent prostate cancer after radical prostatectomy: a comparative study of three definitions

Prostate International
Makito MiyakeKiyohide Fujimoto

Abstract

The clinical management and follow-up of patients with recurrent prostate cancer after salvage radiotherapy (SRT) has not yet been established, and no standardized definition of biochemical recurrence (BCR) after SRT exists. We compared the impact of applying three different definitions of BCR following SRT on patient outcomes and prognostication. Patients who received salvage androgen-deprivation therapy before the completion of SRT were excluded. The data of 118 men who had undergone salvage radiation as monotherapy for BCR after radical prostatectomy were reviewed. In all patients, SRT comprised irradiation to the prostatic bed (70 Gy) using three-dimensional conformal radiotherapy techniques. Treatment outcomes, including BCR-free survival and prognostic factors, were analyzed and compared among three definitions: The Nara, Radiation Therapy Oncology Group (RTOG) 9601, and GETUG-AFU 16 definitions. The BCR rate differed significantly among the applied definitions. Multivariate analyses identified the same four independent prognostic factors, including primary Gleason pattern 4 or 5, negative resection margin, prostate-specific antigen (PSA) level before SRT 0.5 or more, and PSA doubling time before SRT <6 months, using the ...Continue Reading

Citations

Sep 25, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Nobumichi TanakaKiyohide Fujimoto
Nov 26, 2020·Medicine·Xuezhen YangXueping Ma
Jun 7, 2021·Seminars in Radiation Oncology·Ali PirastehIvan Pedrosa
Jul 15, 2021·Physics and Imaging in Radiation Oncology·Vilberg JóhannessonAdalsteinn Gunnlaugsson

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BETA
biopsy
surgical resection

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GraphPad
PRISM
SPSS

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