The impact of the distribution of human papillomavirus types and associated high-risk lesions in a colposcopy population for monitoring vaccine efficacy.

Archives of Pathology & Laboratory Medicine
Nick A AntonishynAlberto Severini

Abstract

Impact studies of the new human papillomavirus (HPV) vaccines will be biased unless local baseline distribution studies are conducted. Vaccine cross protection for other important oncogenic HPV types and the emergence of potential genotype replacements require the knowledge of the prevaccine epidemiology of HPV. To determine the prevaccine distribution of HPV types in Saskatchewan, using a subpopulation of women referred to a colposcopy clinic. One thousand three hundred fifty-five specimens obtained during colposcopic examination were typed for HPV using L1 or E1 gene polymerase chain reaction and direct sequencing. HPV-16 and HPV-31 infections were confirmed with real-time E6 polymerase chain reaction. Indeterminate samples were analyzed using Luminex technology. Correlations of the HPV type and histology were examined for statistical significance. The most commonly identified genotype in patients with cervical intraepithelial neoplasia grade 2 or worse was HPV-16 (46.7%) followed by HPV-31 (14.7%) and then HPV-18 (3.9%). Fifteen of 330 specimens that were positive for HPV-16 or HPV-31 were further resolved to be mixed HPV-16/HPV-31 infections by real-time polymerase chain reaction. The risk of cervical intraepithelial neopla...Continue Reading

References

Apr 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·K V ShahR W Jones
Sep 1, 1996·Journal of Clinical Microbiology·F KarlsenB Hagmar
May 5, 1997·The American Journal of Medicine·L Koutsky
May 29, 1998·Journal of Clinical Pathology·M J ArendsM Wells
Aug 12, 1999·Annals of Medicine·S M Syrjänen, K J Syrjänen
Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Sep 15, 1999·European Journal of Epidemiology·S StraussJ J Gray
May 4, 2000·Journal of the National Cancer Institute·H zur Hausen
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S. A. Southern, C. S. Herrington
Apr 3, 2001·Journal of Cutaneous Medicine and Surgery·J SeversonS K Tyring
Jan 15, 2003·Clinical Microbiology Reviews·Eileen M Burd
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Jun 9, 2004·Virology·Ethel-Michele de VilliersHarald zur Hausen
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gary M CliffordJeanne M Pimenta
Jul 14, 2005·Scandinavian Journal of Infectious Diseases·Mario RassuGiorgio Palu'
Jul 21, 2005·International Journal of Cancer. Journal International Du Cancer·Paul K S ChanMargaret Ip
Jul 29, 2005·Cytopathology : Official Journal of the British Society for Clinical Cytology·E BeerensC A Cuvelier
Nov 16, 2005·Reviews in Medical Virology·Christy M Hebner, Laimonis A Laimins
Feb 4, 2006·Journal of Clinical Microbiology·Markus SchmittTim Waterboer
Feb 4, 2006·Journal of Clinical Microbiology·Wim G V QuintUNKNOWN World Health Organization Human Papillomavirus DNA International Collaborative Study Group
Aug 4, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eileen F Dunne, Lauri E Markowitz
Oct 17, 2006·The Journal of Infectious Diseases·Cosette M WheelerUNKNOWN Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesions Triage Study Group
Mar 1, 2007·JAMA : the Journal of the American Medical Association·Eileen F DunneLauri E Markowitz
Mar 1, 2007·JAMA : the Journal of the American Medical Association·Susan C Weller, Lawrence R Stanberry
Mar 30, 2007·Virology Journal·Manuel Angulo, Antonio Carvajal-Rodríguez
Apr 4, 2007·International Journal of Cancer. Journal International Du Cancer·Jennifer S SmithGary M Clifford

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Citations

May 26, 2010·Infectious Agents and Cancer·Valeria BergonziniGiorgio Palù
Aug 5, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A Carvajal-Rodríguez
Aug 8, 2008·Gynecologic Oncology·Eduardo González-BosquetJose M Lailla
Apr 21, 2009·Diagnostic Microbiology and Infectious Disease·Laura SelvaCarmen Muñoz-Almagro
Oct 13, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Antonella AgodiSalvatore Travali

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