The impact of the glucagon-like peptide 1 receptor agonist liraglutide on the streptozotocin-induced diabetic mouse kidney proteome

Physiological Reports
Leena LiljedahlPeter James

Abstract

In diabetes mellitus (DM), the kidneys are exposed to increased levels of hyperglycemia-induced oxidative stress. Elevated amounts of reactive oxygen species (ROS) are believed to provoke ultrastructural changes in kidney tissue and can eventually result in DM late complications such as diabetic nephropathy. While it is reported that glucagon-like peptide 1 receptors (GLP-1R) are present in the kidney vasculature, the effects of GLP-1 on the kidney proteome in DM is not well described. Thus, we set out to investigate potential effects on the proteomic level. Here the effects of GLP-1R agonism using the GLP-1 analogue liraglutide are studied in the kidneys of streptozotocin (STZ)-treated mice (n = 6/group) by label-free shotgun mass spectrometry (MS) and targeted MS. Unsupervised and supervised multivariate analyses are followed by one-way ANOVA. Shotgun MS data of vehicle and liraglutide-treated mouse groups are separated in the supervised multivariate analysis and separation is also achieved in the subsequent unsupervised multivariate analysis using targeted MS data. The mouse group receiving the GLP-1R agonist liraglutide has increased protein abundances of glutathione peroxidase-3 (GPX3) and catalase (CATA) while the abundan...Continue Reading

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Citations

Jul 23, 2020·Frontiers in Pharmacology·Daiji Kawanami, Yuichi Takashi
May 16, 2020·Drug Discovery Today·Frederikke E SembachLisbeth N Fink
Mar 23, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xin MouWen Hong Liu

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Datasets Mentioned

BETA
PASS00839

Methods Mentioned

BETA
ELISA
PCA

Software Mentioned

DA
OPLS
Progenesis
Mascot
SRM
Normalyzer
Peptide Atlas
Skyline
GraphPad PRISM
Prism

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