The impact of the microbial load of genital mycoplasmas and gestational age on the intensity of intraamniotic inflammation

American Journal of Obstetrics and Gynecology
Marian KacerovskyBo Jacobsson

Abstract

The objective of the study was to determine whether the bacterial load of genital mycoplasmas and gestation age are related to intraamniotic inflammatory response using the amniotic fluid levels of 18 inflammatory mediators. A prospective study of 145 women with singleton pregnancies complicated by preterm prelabor rupture of membranes between 24(0/7) and 36(6/7) weeks was conducted. Amniotic fluid was obtained from all women by transabdominal amniocentesis. The amounts of genital mycoplasma deoxyribonucleic acid were determined using the threshold cycle value and relative and absolute quantification techniques. A panel of multiple proteins was analyzed simultaneously using multiplex technology. Twenty-four women with the presence of genital mycoplasmas in amniotic fluid were included in the final analyses. The concentrations of 9 of the 18 evaluated proteins in the amniotic fluid correlated with bacterial load of genital mycoplasmas independent of the quantification technique used. The intensity of intraamniotic inflammatory response to genital mycoplasmas decreased with gestational age.

References

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Citations

Apr 24, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyCtirad Andrys
May 16, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rovana Paludo ToyamaMaria Marlene de Souza Pires
Nov 6, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ivana MusilovaMarian Kacerovsky
Dec 4, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sun Min KimBo Hyun Yoon
Aug 2, 2015·American Journal of Obstetrics and Gynecology·Roberto RomeroLeonid Margolis
Oct 11, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Salvatore PignanelliMaria Rosaria Catania
Apr 8, 2014·American Journal of Obstetrics and Gynecology·Marian KacerovskyBo Jacobsson
Sep 28, 2015·American Journal of Obstetrics and Gynecology·Amy P Murtha, Ramkumar Menon
Mar 16, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyCtirad Andrys
Jan 24, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyCtirad Andrys
Oct 30, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ctirad AndrysBo Jacobsson
Apr 24, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyBo Jacobsson
Oct 12, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Shubhada BopegamageJochem M D Galama
Jul 25, 2015·PloS One·Ivana MusilovaMarian Kacerovsky
Mar 10, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ivana MusilovaMarian Kacerovsky
Dec 10, 2016·Critical Reviews in Microbiology·Lisa F StinsonJeffrey A Keelan
Mar 10, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ivana MusilovaMarian Kacerovsky
Jun 7, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ivana MusilovaMarian Kacerovsky
Jan 19, 2017·Journal of Perinatal Medicine·Gilbert G G DondersLjubomir Petricevic
Sep 1, 2016·Journal of Perinatal Medicine·Cecilia StalbergRamkumar Menon
Jan 13, 2015·Expert Review of Anti-infective Therapy·Kirsten Glaser, Christian P Speer
May 21, 2015·PloS One·Marian KacerovskyJana Nekvindova
Sep 12, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Richard SpacekMarian Kacerovsky
Jul 6, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyIvana Musilova
Oct 23, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Veronika FulovaRadovan Pilka

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