The impact of the National Cholesterol Education Program Adult Treatment Panel III guidelines on drug development

The American Journal of Cardiology
Jonathan IsaacsohnDavid Orloff

Abstract

In the newest guidelines of the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III, more intensive low-density lipoprotein cholesterol-lowering therapy, together with more attention to other lipid and lipoprotein parameters, are recommended for a larger group of dyslipidemic patients than was covered under ATP I and ATP II. A discussion to evaluate how future drug development might be affected by these new guidelines took place at the 14th International Symposium on Drugs Affecting Lipid Metabolism (DALM) conference, held in New York in September 2001. These discussions involved how to develop new lipid-lowering drugs in an era in which so much compelling evidence demonstrates the benefits of statins. Also covered were issues related to the development of drugs with triglyceride indications and whether the proportion of patients achieving NCEP guidelines should be included in the label of lipid-lowering drugs. Additional topics discussed included: (1) the possibility of incorporating a non-high-density lipoprotein cholesterol (HDL-C) indication for lipid-lowering drugs, (2) the possibility of obtaining indications for lipid-lowering drugs specifically in patients with diabetes, (3) the place of combin...Continue Reading

References

May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults

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Citations

May 24, 2003·Current Diabetes Reports·Michael H Davidson
Feb 4, 2003·Current Atherosclerosis Reports·Dean G Smith
Dec 7, 2002·The American Journal of Cardiology·Michael H Davidson
Dec 10, 2003·Expert Opinion on Emerging Drugs·Anthony S Wierzbicki
Jul 10, 2004·Current Opinion in Lipidology·Michael H Davidson, Peter P Toth
May 6, 2014·Archivos de cardiología de México·Luis GariglioOsvaldo Fridman
Jan 1, 2012·Microbial Ecology in Health and Disease·Eugenia Elefterios Venizelos Bezirtzoglou

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