The impact of the relaxivity definition on the quantitative measurement of glycosaminoglycans in cartilage by the MRI dGEMRIC method.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Shaokuan Zheng, Yang Xia

Abstract

The relaxivities (R-values) of the gadolinium diethylene triamine pentaacetic acid (Gd(DTPA)2-) ions in a series of skim-milk solutions at 0-40% milk concentrations were measured using NMR spectroscopy. The R-value was found to be approximately linearly proportional to the concentration of the solid component in the milk solution. Using the R-value at 20% solid component (approximately the solid concentration in bovine nasal cartilage), the glycosaminoglycan concentration in bovine nasal cartilage can be quantified using the MRI delayed gadolinium-enhanced MRI of cartilage method without the customary scaling factor of 2. This finding is also supported by the measurements using 23Na NMR spectroscopy, 23Na inductively coupled plasma analysis, and biochemical assay. The choice of the R-value definition in the MRI delayed gadolinium-enhanced MRI of cartilage method is discussed, and the definition of Gd(DTPA)2- ions as "millimole per volume of tissue (or milk solution for substitution)" should be used.

References

Jan 1, 1979·Connective Tissue Research·P M Royce, D A Lowther
Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L M LesperanceD Burstein
Jan 1, 1990·Connective Tissue Research·R L Goldberg, L M Kolibas
Jan 1, 1982·Connective Tissue Research·R W FarndaleA J Barrett
Nov 10, 1995·Archives of Biochemistry and Biophysics·Y XiaL W Jelinski
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M DonahueM L Gray
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
Oct 6, 1997·Journal of Magnetic Resonance Imaging : JMRI·Y XiaG Lust
Oct 23, 1997·American Journal of Human Genetics·D W BianchiA P Shuber
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Xia
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
Jun 22, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R G AllenM L Gray
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G J Stanisz, R M Henkelman
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Erik M ShapiroRavinder Reddy
Sep 28, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Miika T NieminenJukka S Jurvelin
Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amy GillisDeborah Burstein
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Carl Johan TideriusLeif Dahlberg
Aug 27, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Didier LaurentMarkus Rudin
Oct 18, 2003·The Journal of Bone and Joint Surgery. American Volume·Young-Jo KimDeborah Burstein
Apr 26, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenneth W FishbeinRichard G Spencer
May 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kenneth W FishbeinRichard G Spencer
Jun 27, 2008·Journal of Magnetic Resonance Imaging : JMRI·Yang XiaAruna Bidthanapally

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Citations

Dec 20, 2011·Osteoarthritis and Cartilage·E-N SaloM T Nieminen
Jul 22, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wei LiPottumarthi V Prasad
Sep 4, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jenny AlgotssonOlle Söderman
Apr 24, 2013·Bone & Joint Research·Y Xia
May 17, 2014·Journal of Magnetic Resonance Imaging : JMRI·Nian WangYang Xia
Oct 21, 2014·Journal of Magnetic Resonance Imaging : JMRI·Vanessa A LukasRichard G Spencer
May 23, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marina BarandunAndrea Barbero
Oct 31, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nian WangYang Xia
Dec 3, 2020·Biomolecules·Alfonso Maria PonsiglioneEnza Torino
Aug 9, 2011·Microscopy Research and Technique·Yang XiaJihyun Lee
Sep 29, 2011·Journal of Magnetic Resonance Imaging : JMRI·Zana K HaweziCarl J Tiderius
Dec 27, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jianhua YinMei Lu

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