The impact of the type and severity of postoperative complications on long-term outcomes following surgery for colorectal cancer: A systematic review and meta-analysis

Critical Reviews in Oncology/hematology
Stephen T McSorleyDonald C McMillan

Abstract

This systematic review investigated the impact of complications by type (infective vs. non-infective) and severity (using the Clavien Dindo scale) on long-term outcome following surgery for colorectal cancer. A systematic review was performed using appropriate keywords. Meta-analysis using a random effects model was performed. 14 studies were included with a total 18,611 patients. Infective complications had a significant impact on disease free (HR 1.41, 95%CI 1.08-1.83, p=0.01) and overall survival (1.37 95%CI 1.22-1.55, p<0.001). Non-infective complications had no significant impact on either disease free (HR 1.21, 95%CI 0.97-1.52, p=0.09) or overall survival (HR 1.35, 95%CI 0.92-1.97, p=0.12). Complication severity had a significant impact on both disease free (HR 1.41, 95%CI 1.18-1.68, p<0.001) and overall survival (HR 1.45, 95%CI 1.25-1.69, p<0.001). Both type and severity of postoperative complications have an impact on long-term survival following surgery for colorectal cancer.

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Citations

Dec 29, 2017·Nature Reviews. Clinical Oncology·Jonathan G HillerErica K Sloan
Jul 25, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K FagardC Kenis
Feb 15, 2020·Annals of Coloproctology·Changkyu Oh, Jung Wook Huh
Mar 14, 2018·International Journal of Colorectal Disease·Eligijus PoskusKestutis Strupas
Feb 6, 2018·World Journal of Gastroenterology : WJG·Katie E RollinsDileep N Lobo
Jul 13, 2017·Surgery Today·Ryota NakanishiYoshihiko Maehara
Oct 7, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Dimitrios SchizasGeorge E Theodoropoulos
Jan 23, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Tina FransgaardIsmail Gögenur
Jun 8, 2021·Annals of Gastroenterological Surgery·Yusuke FujitaUNKNOWN Japan Society of Laparoscopic Colorectal Surgery
Apr 13, 2021·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Lucia GraneroJosé Luis Hernández Lizoáin

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