The impact of third-generation beta-blocker antihypertensive treatment on endothelial function and the prothrombotic state: effects of smoking

American Journal of Hypertension
Gregory P VyssoulisChristodoulos I Stefanadis

Abstract

The significance of beta-blockers in the treatment of cardiovascular diseases is well established. The effect of vasodilating beta-blockers on endothelial function and prothrombotic state has not been investigated. The study comprised 550 consecutive patients with uncomplicated essential hypertension. They were treated with celiprolol, carvedilol or nebivolol monotherapy (171, 179, and 200 patients, respectively), achieving comparable blood pressure reduction. Plasma levels of fibrinogen and homocystine and serum levels of plasminogen activator inhibitor-1 (PAI-1) were obtained before and 6 months after initiation of treatment. The three drugs differentiated in regard to homocystine (P <.00001) and fibrinogen level changes (P =.00003), but not (P = NS) in PAI-1 change. In smokers, differentiation was found in all three parameters (P =.0002, P =.001, and P =.006 for fibrinogen, PAI-1, and homocystine, respectively), but in nonsmokers differentiation was found only in homocystine change (P =.00003). In smokers, fibrinogen, PAI-1, and homocystine were reduced more (P =.002, P =.0009, and P <.0001, respectively) than in nonsmokers in the whole study cohort. The effect of nebivolol was more prominent in smokers than nonsmokers in re...Continue Reading

Citations

Jun 28, 2007·The Canadian Journal of Cardiology·Bahman TarighiSen Nur Azcan
Jul 31, 2007·Expert Opinion on Pharmacotherapy·Rudolf A de BoerDirk J van Veldhuisen
Jun 26, 2015·Drug Development Research·Amal J FataniSalim S Al-Rejaie
Dec 16, 2006·The Journal of Clinical Hypertension·R Preston Mason, John R Cockcroft
Dec 16, 2006·The Journal of Clinical Hypertension·Thomas D Giles
Apr 7, 2007·American Journal of Therapeutics·Zafar H IsrailiManuel Valasco
Aug 23, 2006·Cardiology in Review·Sachin S Sule, William Frishman
Sep 22, 2007·Journal of Hypertension·Charalambos VlachopoulosChristodoulos Stefanadis
Feb 5, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Annabella Braschi
Aug 12, 2005·Journal of Hypertension·Cristiana CatenaLeonardo A Sechi
Jan 18, 2006·Diabetes Research and Clinical Practice·Myeung-Ju KimKee-Wook Jung

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