The impact of using a partially randomised patient preference design when evaluating alternative managements for heavy menstrual bleeding

British Journal of Obstetrics and Gynaecology
Kevin G CooperA M Garratt

Abstract

To identify the advantages and disadvantages of using a partially randomised patient preference design rather than a conventional randomised controlled design when evaluating alternative managements for heavy menstrual bleeding. Randomised controlled comparison of two clinical trial designs with subsequent follow up of the cohorts of women generated. Women attending a general gynaecology clinic for the first time because of heavy menstrual bleeding. Partially randomised patient preference clinical trial design and conventional randomised controlled design. Overall participation; participation in randomised clinical trial of medical management compared with transcervical surgical resection of the endometrium; prognostic characteristics (socio-demographic and Short Form 36) of clinical trial groups; outcomes (clinical and Short Form 36) of clinical trial groups. Overall, more women participated in the partially randomised patient preference design (130/135 vs 97/138; difference 27%, 95% CI 18% to 34%) but there was no difference in the numbers who agreed to be randomised (90/135 vs 97/138; difference-3%, 95% CI-15% to 7%). Women who chose medical management tended to have better general health, to be less restricted by their mens...Continue Reading

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