The impact of using different imputation methods for missing quality of life scores on the estimation of the cost-effectiveness of lung-volume-reduction surgery

Health Economics
David K BloughNett Research Group

Abstract

A post hoc analysis of data from a prospective cost-effectiveness analysis (CEA) conducted alongside a randomized controlled trial (National Emphysema Treatment Trial - NETT) was used to assess the impact of using different imputation methods for missing quality of life data on the estimation of the incremental cost-effectiveness ratio (ICER). The NETT compared lung-volume-reduction surgery plus medical therapy with medical therapy alone in patients with severe chronic obstructive pulmonary disease due to emphysema. One thousand sixty-six patients were followed for up to 3 years after randomization. The cost per quality-adjusted life-year gained was obtained, computing costs from a societal perspective and using the self-administered Quality of Well Being questionnaire to measure quality of life. Different methods of imputation resulted in substantial differences in ICERs as well as differences in estimates of the uncertainty in the point estimates as reflected in the CEA acceptability curves. Paradoxically, the use of a conservative single imputation method resulted in relatively less uncertainty (anticonservative) about the ICER. Owing to the effects of different imputation methods for missing quality of life data on the esti...Continue Reading

References

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Citations

Jul 17, 2012·The Medical Clinics of North America·Jonathan P Singer, Roger D Yusen
Dec 5, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Claire L SimonsJudit Simon
May 20, 2016·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Lukas KwietniewskiJonas Schreyögg
Aug 6, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Manuel GomesMichael G Kenward
May 20, 2016·PharmacoEconomics·Alan Haycox
Mar 14, 2014·International Journal of Technology Assessment in Health Care·Jayne TaylorBruce Campbell
Aug 16, 2014·Frontiers in Human Neuroscience·Ezequiel Alejandro Di PaoloThomas Buhrmann
May 16, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Iris H L MaesManuela A Joore
Feb 29, 2020·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Bernhard MichalowskyFeng Xie
May 28, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Naazish S BashirWendy J Ungar

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