The Impact of Using Different Reference Populations on Measurement of Breast Cancer-Related Cognitive Impairment Rates.

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
Jonathan D ClappThinking and Living with Cancer (TLC) Study

Abstract

To evaluate how use of different reference populations affects estimates of breast cancer-related cognitive impairment rates. Patients aged ≥60 years with stage 0-3 breast cancer (n = 371) and matched non-cancer controls (n = 370) completed 13 neuropsychological tests prior to systemic therapy or at enrollment (controls). The tests captured three domains: attention, processing speed and executive function; learning and memory; and visual-spatial function. Domain-specific impairment was defined as having one test score 2 SD below or two or more test scores 1.5 SD below the reference population means. Different reference populations were used to define impairment: published normative data, study-specific controls, age and education-stratified controls, and age and education-adjusted controls. The associations between the resultant impairment rates and breast cancer (vs. control) were evaluated using chi-square tests and logistic regression models. Cohen's kappa coefficients were used to evaluate agreement of impairment rates between study-specific control performance and the other reference population groups. The patients and controls were aged 68.0 (SD 6.0) and 67.9 (SD 7.0) years, respectively. The association of breast cancer-...Continue Reading

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Citations

Nov 28, 2018·Journal of Clinical and Experimental Neuropsychology·Noemí CerullaLuís Fernández-Morales
Sep 10, 2019·Journal of the National Cancer Institute·Kimberly D van der WillikSanne B Schagen
Nov 19, 2019·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Paula PintoNuno Lunet
Sep 26, 2019·Cancer·Judith E CarrollUNKNOWN Thinking and Living With Cancer Study
Mar 18, 2021·Journal of Cancer Survivorship : Research and Practice·Simone OerlemansLonneke V van de Poll-Franse

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