PMID: 9641282Jun 26, 1998Paper

The impact of vasodilators on random-pattern skin flap survival in the rat following mainstream smoke exposure

Annals of Plastic Surgery
B W DaviesG Pennington

Abstract

This study demonstrates that acute mainstream cigarette smoke exposure is deleterious to dorsal random-pattern skin flap survival in the rat. Three vasodilators were also studied for their ability to mediate flap survival after smoke exposure. Sprague-Dawley rats (10 per group) were exposed to two cigarettes per day over a 14-day period. This is an exposure equivalent to that of an average cigarette smoker. Dorsal McFarlane caudally based random-pattern skin flaps (4 x 10 cm) were created on day 7 of the smoke exposure. Enteral phenoxybenzamine (0.56 mg per kilogram per day), enteral nifedipine (10 mg per kilogram per day), and topical nitroglycerin (1.3 cm or 7.5 mg per day) were administered after creation of the dorsal skin flaps in two doses daily during smoke exposure. Fluorescein was used to delineate areas of viability accurately. A pad digitizer was utilized to calculate designated skin flap areas to +/-1.0 mm2. Experimental animals demonstrated a 23% decrease (p < 0.01) in skin flap area survival compared with the control animals. The phenoxybenzamine group demonstrated a 5.5% increase in flap area survival (p=0.068), the nifedipine group demonstrated a 4.1% increase in flap area survival (p=0.049), and the nitroglycer...Continue Reading

Citations

Jun 10, 2000·International Journal of Dermatology·S R KarukondaL E Millikan
Sep 8, 2001·Plastic and Reconstructive Surgery·J K Krueger, R J Rohrich
Jan 30, 2013·Plastic and Reconstructive Surgery·Devin CoonSteven C Bonawitz
Aug 27, 2010·The Journal of Surgical Research·Frederico A S FreitasWerther G Marchesan
Mar 13, 2014·Microsurgery·Ajul ShahDerek M Steinbacher
Oct 1, 2008·Current Therapeutic Research, Clinical and Experimental·Kaan GiderogluGuler Bugdayci
Oct 16, 2015·Acta Cirúrgica Brasileira·Cristina Pires CamargoRolf Gemperli
May 17, 2018·Acta Cirúrgica Brasileira·André PazioGuataçara Schenfelder Salles Junior
Feb 21, 2008·Microsurgery·Vince BattistaE F Shaw Wilgis
Jul 22, 2005·Annals of Plastic Surgery·Teoman Eskitascioglu, Galip Kemali Gunay
Dec 11, 2013·Annals of Plastic Surgery·Anajara GazzalleJefferson Luis Braga-Silva
Feb 15, 2013·Annals of Plastic Surgery·Hidir KilincAysun Bay Karabulut
Jun 22, 2013·Annals of Plastic Surgery·Irfan Ozyazgan, Halit Baykan
May 23, 2009·Annals of Plastic Surgery·Hamidreza Pazoki-ToroudiAlireza Firooz
Apr 2, 2019·Journal of Plastic Surgery and Hand Surgery·Dincer AltınelSevgi Kurt Yazar
Dec 2, 2005·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Zekeriya TosunNedim Savaci

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