Abstract
To estimate the impact of treatment with middle ear ventilation tube insertion (VTI) in children with otitis media (OM) on the risk of cholesteatoma on a national level. Data were obtained from the Danish National Patient Register, the National Health Service Register and Statistics Denmark. Cumulative incidence proportions were estimated by the Kaplan-Meier method and hazard ratios with Cox regression analysis. The first surgically treated middle ear cholesteatoma in a child (STMEC1) was considered an event. A total of 217,206 children, born after December 31, 1996, who had VTI from January 1, 1997 to August 31, 2011 were identified. Of these, 374 subsequently had a STMEC1. A corresponding 36,981 children without any VTI were identified for comparison using a random 5% sample of the Danish population. Of these, 5 had a STMEC1. The cumulative incidence proportion with STMEC1 at 12 years of age for children with 0, 1, 2, 3, and ≥4 VTI's was 0.04% (95% confidence interval 0.02-0.12%), 0.21% (0.18-0.26%), 0.35% (0.28-0.43%), 0.40% (0.30-0.54%), and 0.55% (0.44-0.70%), respectively. In the regression model each additional year of age before the first VTI increased the risk of STMEC1 by 54% (47-63%), while each additional year betwe...Continue Reading
References
Apr 1, 1990·Clinical Otolaryngology and Allied Sciences·G A ZielhuisP Van den Broek
Mar 1, 1997·Pediatrics·J L ParadiseJ E Janosky
Jul 16, 1999·Archives of Otolaryngology--head & Neck Surgery·A GolzH Z Joachims
Jul 11, 2006·International Journal of Pediatric Otorhinolaryngology·Fatma Homood Al Anazy
Nov 23, 2006·Archives of Otolaryngology--head & Neck Surgery·Katrina SpilsburyFrancis J Lannigan
Jun 4, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Per Cayé-ThomasenMirko Tos
Jan 9, 2010·The Laryngoscope·Katrina SpilsburyFrancis J Lannigan
Aug 4, 2011·Scandinavian Journal of Public Health·Carsten Bøcker Pedersen
Aug 4, 2011·Scandinavian Journal of Public Health·John Sahl AndersenAllan Krasnik
Sep 3, 2011·Paediatrics & Child Health·Elaina A MacintyreMichael Brauer
Jan 24, 2012·International Journal of Pediatric Otorhinolaryngology·Diego A Preciado
Jun 20, 2013·The Laryngoscope·Neil C-W TanPeter-John Wormald
Apr 16, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christian Hamilton HeidemannChristian Godballe
Jul 27, 2014·International Journal of Pediatric Otorhinolaryngology·Bjarki Ditlev DjurhuusChristian Emil Faber
Dec 17, 2014·International Journal of Pediatric Otorhinolaryngology·Bjarki Ditlev DjurhuusChristian Emil Faber
Citations
Feb 10, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Ville LehtonenVuokko Anttonen
Mar 1, 2016·Acta Oto-laryngologica·B D DjurhuusK Christensen
Feb 23, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jason A BeyeaStephen F Hall
Feb 20, 2020·BMC Pediatrics·Jason A BeyeaPaul Nguyen
Mar 15, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jason A BeyeaStephen F Hall
Jun 1, 2017·Pediatrics·Dale W SteeleThomas A Trikalinos