The Impact of Vitamin C on Different System Models of Werner Syndrome.

Antioxidants & Redox Signaling
Lucie Aumailley, Michel Lebel

Abstract

Significance: Werner syndrome (WS) is a rare autosomal recessive malady typified by a pro-oxidant/proinflammatory status, genetic instability, and by the early onset of numerous age-associated illnesses. The protein malfunctioning in WS individuals (WRN) is a helicase/exonuclease implicated in transcription, DNA replication/repair, and telomere maintenance. Recent Advances: In the last two decades, a series of important biological systems were created to comprehend at the molecular level the effect of a defective WRN protein. Such biological tools include mouse and worm (Caenorhabditis elegans) with a mutation in the Wrn helicase ortholog as well as human WS-induced pluripotent stem cells that can ultimately be differentiated into most cell lineages. Such WS models have identified anomalies related to the hallmarks of aging. Most importantly, vitamin C counteracts these age-related cellular phenotypes in these systems. Critical Issues: Vitamin C is the only antioxidant agent capable of reversing the cellular aging-related phenotypes in those biological systems. Since vitamin C is a cofactor for many hydroxylases and mono- or dioxygenase, it adds another level of complexity in deciphering the exact molecular pathways affected by...Continue Reading

References

Apr 1, 1990·European Journal of Clinical Investigation·S MoriS Yoshida
Jan 1, 1985·Advances in Experimental Medicine and Biology·G M Martin
Jan 1, 1985·Advances in Experimental Medicine and Biology·M GotoT Miyamoto
Apr 12, 1996·Science·C E YuG D Schellenberg
May 3, 1996·Science·J L Breslow
Sep 1, 1997·Nature Genetics·M D GrayL A Loeb
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Lebel, P Leder
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·N MaedaR Reddick
Mar 23, 2000·Biochimica Et Biophysica Acta·G L Simpson, B J Ortwerth
Apr 11, 2000·Molecular and Cellular Biology·D B LombardL Guarente
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S T NadlerA D Attie
Jul 13, 2002·Trends in Biochemical Sciences·Thomas von Zglinicki
Aug 3, 2002·Journal of Neurochemistry·Antonio MartinAna Maria Cuervo
Jun 13, 2003·Genome Biology·Wim Verelst, Han Asard
Jul 5, 2003·Genes & Development·Carla GrandoriRaymond J Monnat
Aug 5, 2003·BioFactors·Gábor BánhegyiJózsef Mandl
Dec 16, 2003·British Journal of Plastic Surgery·E K Yeong, C C Yang
Jul 6, 2004·Nature Genetics·Sandy ChangRonald A DePinho
Jul 16, 2004·Molecular and Cellular Biology·Juan M CárcamoDavid W Golde
Sep 3, 2004·Journal of the American Geriatrics Society·Koutaro YokoteYasushi Saito
Nov 25, 2004·Experimental Cell Research·Michael V Miceli, S Michal Jazwinski
Sep 6, 2005·The Journal of Biological Chemistry·Maria A K WestinStefan E H Alexson
Sep 6, 2005·Journal of Cell Science·Li LanAkira Yasui
Oct 28, 2005·The Journal of Nutrition·Eva MargittaiMiklós Csala
Nov 17, 2005·Molecular and Cellular Biology·Anna M SzekelySherman M Weissman
Dec 8, 2005·Biogerontology·Giovanni PaganoSeiji Kodama
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Terence DavisDavid Kipling
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Jan 16, 2007·The FEBS Journal·Carole L Linster, Emile Van Schaftingen
Feb 27, 2007·Free Radical Biology & Medicine·Margret C M VissersMargaret J Currie

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Methods Mentioned

BETA
protein folding
imaging techniques

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