The impact of within-vector parasite development on the extrinsic incubation period

Royal Society Open Science
Lauren M Childs, Olivia F Prosper

Abstract

Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading to nearly half a million deaths each year. The malaria parasite requires a vertebrate host, such as a human, and a vector host, the Anopheles mosquito, to complete its full life cycle. Here, we focus on the parasite dynamics within the vector to examine the first appearance of sporozoites in the salivary glands, which indicates a first time of infectiousness of mosquitoes. The timing of this period of pathogen development in the mosquito until transmissibility, known as the extrinsic incubation period, remains poorly understood. We develop compartmental models of within-mosquito parasite dynamics fitted with experimental data on oocyst and sporozoite counts. We find that only a fraction of oocysts burst to release sporozoites and bursting must be delayed either via a time-dependent function or a gamma-distributed set of compartments. We use Bayesian inference to estimate distributions of parameters and determine that bursting rate is a key epidemiological parameter. A better understanding of the factors impacting the extrinsic incubation period will aid in the development of interventions to slow or stop the spread of malaria.

References

Jun 23, 2005·The Journal of Biological Chemistry·Luc ReiningerChristian Doerig
Oct 21, 2005·Trends in Parasitology·Luke A Baton, Lisa C Ranford-Cartwright
Jan 2, 2008·PLoS Pathogens·Robert E SindenMaría-Gloria Basáñez
Jun 24, 2008·Journal of Theoretical Biology·Simeone MarinoDenise E Kirschner
Apr 8, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Emma J DawesMaría-Gloria Basáñez
Feb 15, 2011·Eukaryotic Cell·Noel GeraldSanjai Kumar
Jul 23, 2011·Malaria Journal·Sandip MandalSomdatta Sinha
Dec 23, 2011·Biology Letters·Krijn P PaaijmansMatthew B Thomas
Mar 23, 2012·Proceedings. Biological Sciences·Philip L F JohnsonRustom Antia
Feb 15, 2013·Journal of the Royal Society, Interface·Robert C ReinerDavid L Smith
Jul 15, 2016·Proceedings. Biological Sciences·Lillian L M ShapiroMatthew B Thomas
Dec 17, 2016·Nature Communications·Chiara CurràInga Siden-Kiamos
May 26, 2017·PloS One·Lauren M Childs, Olivia F Prosper
Mar 14, 2018·Parasites & Vectors·Johanna R OhmMatthew B Thomas

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