The impact of worsening renal function with elevated B-type natriuretic peptide at discharge on 1-year prognosis in heart failure patients

Scientific Reports
Toshitaka OkabeMasahiko Ochiai

Abstract

There are a few studies about the clinical impacts of plasma B-type natriuretic peptide (BNP) at discharge with the occurrence of worsening renal function (WRF) on mortality in patients with heart failure (HF). We divided total 301 patients with acute decompensated HF into four groups by the median value (278.7 pg/mL) of BNP level at discharge and by the occurrence of WRF. WRF developed in 100 patients (33.2%). Cardiovascular mortality was significantly different between the four groups (P = 0.0002). Patients with WRF and elevated BNP had a higher cardiovascular mortality than patients without WRF and elevated BNP in Cox proportional hazard models (hazard ratio [HR], 10.48; 95% confident interval [95% CI], 1.27-225.53; P = 0.03). Patients with either WRF or elevated BNP did not have an increased risk of cardiovascular mortality compared to patients without WRF and elevated BNP. Regarding HF readmission and cardiovascular mortality, patients with WRF and elevated BNP had the highest risk (HR, 5.17; 95% CI, 2.07-14.30, P = 0.0003) and patients with either WRF or elevated BNP had a higher risk than patients without WRF and elevated BNP. The occurrence of WRF combined with elevated BNP at discharge was associated with increased 1-y...Continue Reading

References

Aug 7, 2007·Journal of Cardiac Failure·J Thomas HeywoodUNKNOWN ADHERE Scientific Advisory Committee and Investigators
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Nov 26, 2010·European Journal of Heart Failure·Heiko UthoffChristian Mueller
May 24, 2011·The American Journal of Cardiology·Masaharu NakayamaHiroaki Shimokawa
Jul 14, 2012·Critical Care : the Official Journal of the Critical Care Forum·Chun-Fu LaiUNKNOWN National Taiwan University Hospital Study Group on Acute Renal Failure (NSARF)
Aug 8, 2012·Critical Care : the Official Journal of the Critical Care Forum·Claudio Ronco, Mitchell H Rosner
Feb 24, 2015·The American Journal of Cardiology·Malak WattadDoron Aronson
Dec 26, 2015·Journal of Cardiac Failure·Lauren B CooperJoseph G Rogers
Jun 22, 2016·European Journal of Heart Failure·Maria G Crespo-LeiroUNKNOWN Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Jan 1, 2017·International Journal of Cardiology·Toshitaka OkabeMasahiko Ochiai
Aug 25, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Takayuki InomataUNKNOWN Kanagawa Aquaresis Investigators
Jul 28, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Faeq Husain-SyedClaudio Ronco

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