Abstract
It is well established that the different antipsychotics used for schizophrenia symptoms differ substantially in their side effects. However, relatively little is known about the impact of these side effects on functioning from the patient's perspective. We aimed to understand how key side effects of second-generation antipsychotics impact the functioning and quality of life (QoL) of patients with schizophrenia. This is a cross-sectional, web-based survey of patient-reported side effect burden of antipsychotic drugs in adults with schizophrenia. The survey was deployed in the United States, Canada, Australia, Spain, Italy, Norway, and Denmark. It included sociodemographic and clinical questions, the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form (Q-LES-Q-SF), and the Glasgow Antipsychotic Side-Effect Scale (GASS). Eight pre-defined key side effects classified as activating ("Shaky hands or arms," "Restlessness," and "Difficulty sleeping"), sedating ("Sleepy during the day", "Feeling drugged or like a zombie," and "Feeling dizzy/Fainted") or other side effects ("Problems enjoying sex" and "Gaining weight"), and additional questions related to impacts on function and quality of life were asked. In total, 435 ...Continue Reading
References
Jan 1, 1997·The American Journal of Psychiatry·M AtkinsonH Chuang
Jun 8, 2002·European Psychiatry : the Journal of the Association of European Psychiatrists·Pierre-Michel LlorcaChristophe Lancon
Dec 31, 2002·Psychoneuroendocrinology·R Tandon, U Halbreich
May 27, 2005·PLoS Medicine·Dinesh Bhugra
Aug 16, 2006·Psychological Medicine·Eric Q WuRonald Kessler
May 5, 2007·Schizophrenia Research·Martin StrassnigRohan Ganguli
Sep 7, 2007·Acta Psychiatrica Scandinavica·P H Lysaker, M P Salyers
Apr 11, 2008·Schizophrenia Bulletin·Mary V Seeman
Jun 11, 2008·Journal of Psychopharmacology·L Waddell, M Taylor
Mar 22, 2012·BMC Psychiatry·Marco DibonaventuraEdward Kim
Nov 14, 2012·Journal of Psychiatric and Mental Health Nursing·K UsherK Foster
Jul 3, 2013·Lancet·Stefan LeuchtJohn M Davis
Aug 26, 2014·Schizophrenia Research·Barton W PalmerDilip V Jeste
Sep 14, 2014·Asian Journal of Psychiatry·Dawn BruijnzeelRajiv Tandon
Dec 18, 2014·Journal of Psychopharmacology·Su Ling YoungStephen M Lawrie
May 10, 2015·British Medical Bulletin·John Lally, James H MacCabe
Nov 11, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Trude Seselie Jahr IversenErik G Jönsson
May 12, 2019·Neuropharmacology·Mary V Seeman
Citations
Aug 15, 2020·Annals of General Psychiatry·Rajiv TandonDavid Castle
Jan 16, 2021·PloS One·Sarah ReeveDaniel Freeman
Apr 27, 2021·Frontiers in Psychiatry·Mary V Seeman
Apr 23, 2021·Neuropsychiatric Disease and Treatment·Mizue IchinoseHirooki Yabe
May 13, 2021·Journal of Neural Transmission·Johanna SeifertWaldemar Greil
Aug 10, 2021·International Journal of General Medicine·Ilena PochieroChristoph Correll
Aug 27, 2021·Frontiers in Psychiatry·María Paz García-PortillaJulio Bobes