The impact on health-related quality of life in the first 12 months: A randomised comparison of preoperative short-course radiation versus long-course chemoradiation for T3 rectal cancer (Trans-Tasman Radiation Oncology Group Trial 01.04)

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Sue-Anne McLachlanSamuel Y Ngan

Abstract

To assess health-related quality of life (HRQOL) in patients participating in a randomised trial of neoadjuvant short course radiation (SC) or long course chemoradiation (LC) for operable rectal cancer. Eligible patients with T3N0-2M0 rectal cancer completed the European Organisation for Research and Treatment of Cancer quality of life questionnaire (QLQ-C30) and the colorectal cancer specific module (QLQ C38) at randomisation and 1, 2, 3, 6, 9 and 12 months later. Of 326 patients randomised, 297 (SC 143, LC 154) were eligible for completion of HRQOL questionnaires. Baseline scores were comparable across the SC and LC groups. Patients reported low scores on sexual functioning and sexual enjoyment. Defaecation problems were the worst of the symptoms at baseline. Surgery had the most profoundly negative effect on HRQOL, seen in both the SC and LC treatment groups to the same extent. The most severely affected domains were physical function and role function and the most severely affected symptoms were fatigue, pain, appetite, weight loss and male sexual problems. Most domains and symptoms returned to baseline levels by 12 months apart from body image, sexual enjoyment and male sexual problems. Future perspective was better than p...Continue Reading

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Citations

Oct 19, 2016·Expert Review of Gastroenterology & Hepatology·Chiara Molinari, Alessandro Passardi
Apr 6, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Daniel W KauffWerner Kneist
Jul 16, 2017·Langenbeck's Archives of Surgery·An Ngo-HuangMatthew H G Katz
Jul 17, 2018·The American Journal of Gastroenterology·Benjamin A GoldenbergHarminder Singh
May 30, 2019·International Journal of Surgical Oncology·Omer SagerMurat Beyzadeoglu
May 13, 2017·International Journal of Colorectal Disease·V CelentanoM Chand
Jul 8, 2020·Current Colorectal Cancer Reports·Shane S NeibartSalma K Jabbour
Jul 8, 2020·International Journal of Radiation Oncology, Biology, Physics·Joanna SochaKrzysztof Bujko
Oct 25, 2020·Practical Radiation Oncology·Jennifer Y WoPrajnan Das
Aug 11, 2020·Practical Radiation Oncology·David G Wallington, Emma B Holliday
Dec 5, 2021·Journal of Medical Imaging and Radiation Oncology·Vikneswary BatumalaiMichael B Barton

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