The Impact on Survival and Morbidity of Portal-Mesenteric Resection During Pancreaticoduodenectomy for Pancreatic Head Adenocarcinoma: A Systematic Review and Meta-Analysis of Comparative Studies

Cancers
Alessandro FancelluGiuseppe Nigri

Abstract

Background: The literature is conflicting regarding oncological outcome and morbidity associated to portal-mesenteric resection during pancreaticoduodenectomy (PD) in patients with pancreatic head adenocarcinoma (PHAC). Methods: A meta-analysis of studies comparing PD plus venous resection (PD+VR) and standard PD exclusively in patients with adenocarcinoma of the pancreatic head was conducted. Results: Twenty-three cohort studies were identified, which included 6037 patients, of which 28.6% underwent PD+VR and 71.4% underwent standard PD. Patients who received PD+VR had lower 1-year overall survival (OS) (odds radio OR 0.79, 95% CI 0.67-0.92, p = 0.003), 3-year OS (OR 0.72, 95% CI 0.59-0.87, p = 0.0006), and 5-year OS (OR 0.57, 95% CI 0.39-0.83, p = 0.003). Patients in the PD+VR group were more likely to have a larger tumor size (MD 3.87, 95% CI 1.75 to 5.99, p = 0.0003), positive lymph nodes (OR 1.24, 95% CI 1.06-1.45, p = 0.007), and R1 resection (OR 1.74, 95% CI 1.37-2.20, p < 0.0001). Thirty-day mortality was higher in the PD+VR group (OR 1.93, 95% CI 1.28-2.91, p = 0.002), while no differences between groups were observed in rates of total complications (OR 1.07, 95% CI, 0.81-1.41, p = 0.65). Conclusions: Although PD+VR ha...Continue Reading

References

Dec 17, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Thomas J HowardLee McHenry
Dec 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jennifer F TsengDouglas B Evans
May 17, 2006·The British Journal of Surgery·H P P Siriwardana, A K Siriwardena
Jul 21, 2006·World Journal of Surgery·Nicolas CarrèreJacques Belghiti
Apr 28, 2009·International Journal of Radiation Oncology, Biology, Physics·Boris HristovJoseph M Herman
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Feb 25, 2010·World Journal of Gastroenterology : WJG·K Dilip ChakravartyMiin-Fu Chen
Dec 25, 2010·Surgical Endoscopy·Giuseppe R NigriMarcovalerio Melis
Nov 8, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V M BanzD F Mirza
Feb 7, 2012·Annals of Vascular Surgery·Ryan S TurleyRebekah R White
Apr 27, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kaitlyn J KellySharon M Weber
Oct 30, 2013·ANZ Journal of Surgery·Iraklis PerysinakisIlias Margaris
Feb 4, 2014·Journal of the American College of Surgeons·Reena RavikumarUNKNOWN UK Vascular Resection in Pancreatic Cancer Study Group
Feb 25, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·X Z YuC Jin
May 27, 2014·Surgery·Maximilian BockhornUNKNOWN International Study Group of Pancreatic Surgery
Apr 17, 2015·The British Journal of Surgery·Y MurakamiUNKNOWN Multicentre Study Group of Pancreatobiliary Surgery (MSG-PBS)
Aug 4, 2015·Clinics and Practice·Claudio PuscedduGiovanni Battista Meloni
Aug 11, 2015·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Wei-Lin WangShu-Sen Zheng
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M DucreuxUNKNOWN ESMO Guidelines Committee
Jan 8, 2016·Langenbeck's Archives of Surgery·Hryhoriy LapshynDirk Bausch
Jan 16, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Alexandra M RochC Max Schmidt
Nov 25, 2016·Annals of Surgical Oncology·Gyulnara G KasumovaJennifer F Tseng
Jan 4, 2017·Surgery·Claudio BassiUNKNOWN International Study Group on Pancreatic Surgery (ISGPS)
Apr 14, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J W GilbertM Rosenthal
Jun 13, 2017·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Alessandro FancelluAlberto Porcu

❮ Previous
Next ❯

Citations

May 1, 2021·Cancers·Kongyuan Wei, Thilo Hackert
Nov 9, 2021·Future Oncology·Monish Karunakaran, Savio George Barreto
Nov 10, 2021·Langenbeck's Archives of Surgery·Anna Nießen, Thilo Hackert

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
pancreatectomy

Software Mentioned

PRISMA
RevMan

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.