The impacts of acid suppression on duodenal microbiota during the early phase of severe acute pancreatitis.

Scientific Reports
Xiao MaChengwei Tang

Abstract

Duodenal dysbiosis may be potential infection risks in patients with severe acute pancreatitis (SAP). Acid-suppression drugs (ACDs) are widely used in SAP patients in Asian countries. However, the impact of ACDs on duodenal microbiota during the early phase of SAP is still unknown. This randomized controlled clinical trial evaluated the impacts of esomeprazole (Eso), one of ACDs on duodenal microbiota during the first week of SAP with duodenal aspirates culture and 16sRNA Illumina sequencing analysis. 66 patients were randomized as 1:1 ratio into Eso group (Eso 40 mg/day) and Eso-N group (no Eso). The occurrence of duodenal bacterial overgrowth (DBO) was significantly higher in Eso group (about 85%) than that in Eso-N group (about 42%). The duodenal microbiota of the SAP patients shifted away from that of the normal control. There were differences between the Eso-N and Eso groups including enriched abundances of the class Negativicutes, order Selenomonadales and genus Veillonella. Acid suppression significantly increased incidence of Candida oesophagitis (CE) by 8-folds but did not increase other infectious events. In conclusion, acid suppression greatly increased the occurrence of DBO, duodenal dysbiosis and CE during the firs...Continue Reading

References

Aug 6, 1998·Alimentary Pharmacology & Therapeutics·S P PereiraR H Dowling
Jun 6, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I D Van FeliusH G Gooszen
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Jun 28, 2011·Genome Biology·Nicola SegataCurtis Huttenhower
Apr 10, 2012·Nature Biotechnology·Deepak ReyonJ Keith Joung
Oct 27, 2012·Gut·Peter A BanksUNKNOWN Acute Pancreatitis Classification Working Group
Dec 18, 2012·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jeong Hwan YooPil Won Park
Dec 29, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wai-Kit Lo, Walter W Chan
Jan 12, 2013·Digestive Diseases and Sciences·Kyung-Yup KimYoung Woon Chang
Jun 29, 2013·Current Opinion in Infectious Diseases·Ying Taur, Eric G Pamer
Jul 6, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·N AsayamaN Uemura
Jul 11, 2013·Critical Care : the Official Journal of the Critical Care Forum·Maxim S Petrov
Oct 8, 2013·Nature Reviews. Immunology·Charlie G Buffie, Eric G Pamer
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Jan 21, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A ErdoganC Badger
Apr 3, 2015·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·H W Daniell
Aug 25, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Atsuhiko MurataShinya Matsuda
Oct 27, 2015·Nature Reviews. Microbiology·Gregory P DonaldsonSarkis K Mazmanian
Dec 15, 2015·Gut·Floris ImhannAlexandra Zhernakova
Jan 1, 2016·Gut·Matthew A JacksonClaire J Steves
Dec 14, 2016·The New England Journal of Medicine·Chris E ForsmarkC Mel Wilcox
Jan 23, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Margot E CohenDaniel E Freedberg
Mar 23, 2017·The American Journal of Gastroenterology·Ali RezaieMark Pimentel
Sep 28, 2017·Annals of Nutrition & Metabolism·Ravinder Nagpal, Hariom Yadav
Nov 28, 2017·Current Opinion in Microbiology·Marissa J PatersonDavid M Underhill
Feb 8, 2018·Gastroenterology·Seth D CrockettUNKNOWN American Gastroenterological Association Institute Clinical Guidelines Committee
Apr 28, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Patrick HoverstenDavid A Katzka

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Methods Mentioned

BETA
Illumina sequencing
PCR
electrophoresis

Software Mentioned

Silva
QIIME
R
GraphPad Prism
LEfSe
PRIMER

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