The Impairment of Trans Fatty Acids on Learning, Memory and Brain Amino Acid Neurotransmitters in Mice

Journal of Nutritional Science and Vitaminology
Tiantian ZhangShuang Nie

Abstract

The aim of the study was to demonstrate the impairment of trans fatty acids (TFAs) in neurological disorders in mice. Forty-eight male Kunming mice were randomly divided into four groups with twelve in each group, namely a control group (corn oil group), and TFA groups with low, middle and high dosages. The tested chemicals were given by gavage, once a day, for 12 wk in total, with the volume of the intragastric liquid as 0.1 mL/10 g of body weight. The mice in the control group were given corn oil only. The mice in the TFA groups were given TFA solution (doses were 25, 50 and 100 mg/kg of body weight, respectively). The Morris circle water maze was used to test learning and memory of mice. The activity of acetylcholinesterase (AChE), nitric oxide synthase (NOS) and the level of brain amino acid neurotransmitters were tested. In the Morris water maze task, and compared to the control group, TFAs showed no obvious effect on learning or memory. TFA intake led to a significant decrease of AChE in all TFA groups, and the increase in levels of NOS in the high-dose group. Meanwhile, intake of TFAs increased the levels of Asp, Glu, Gly, and Tau in all TFA groups. The results suggest that long-term intake of TFAs probably impairs learn...Continue Reading

References

Sep 23, 2011·Journal of Neuropathology and Experimental Neurology·Gang XuHannah C Kinney
Jan 3, 2012·The Journal of Nutritional Biochemistry·Marcus O W GrimmTobias Hartmann
Jul 24, 2012·International Journal of Cancer. Journal International Du Cancer·Ida LaakeMarit B Veierød
Jun 18, 2015·PloS One·Beatrice Alexandra Golomb, Alexis K Bui

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