The Impella Device: Historical Background, Clinical Applications and Future Directions

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
James J Glazier, Amir Kaki

Abstract

The Impella device is a catheter-based miniaturized ventricular assist device. Using a retrograde femoral artery access, it is placed in the left ventricle across the aortic valve. The device pumps blood from left ventricle into ascending aorta and helps to maintain a systemic circulation at an upper rate between 2.5 and 5.0 L/min. This results in almost immediate and sustained unloading of the left ventricle, while increasing overall systemic cardiac output. The most common indications for using the Impella device are in the treatment of acute myocardial infarction complicated by cardiogenic shock and to facilitate high risk coronary angioplasty. Other indications include the treatment of cardiomyopathy with acute decompensation, postcardiotomy shock, and off-pump coronary bypass surgery. A growing body of observational and registry data suggest a potentially valuable role for the Impella system in reducing the mortality associated with cardiogenic shock. However, there are, as of yet, no randomized controlled trial data supporting this observation.

Citations

Jul 17, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shannon M FernandoKwadwo Kyeremanteng
Jan 28, 2021·ClinicoEconomics and Outcomes Research : CEOR·Alexandre Le GuyaderGuillaume Lebreton
Mar 18, 2021·Curēus·Alexander D GhannamJohn Pirris
Apr 3, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·H ClaassenA Wree
May 25, 2021·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·James J GlazierAmir Kaki
Nov 7, 2021·European Heart Journal. Acute Cardiovascular Care·Jasmine Melissa Madsen, Thomas Engstrøm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.