The implications of 18F-FDG PET for the diagnosis of endoprosthetic loosening and infection in hip and knee arthroplasty: results from a prospective, blinded study

BMC Musculoskeletal Disorders
K-St DelankP Eysel

Abstract

The most frequent complications of joint arthroplasty are septic or aseptic loosening of endoprostheses. Preoperative differentiation is essential, since very different treatment methods result from the diagnoses. The aim of the current study was to evaluate the clinical value of 18F-Fluoro-deoxyglucose positron emission tomography (18F-FDG PET) as a diagnostic modality for inflammation and loosening in hip and knee joint prostheses. 18F-FDG-PET examinations and multiphase bone scan were performed on hip and knee endoprostheses in 27 patients prior to revision surgical procedures planned for prosthetic loosening. Intact prostheses were found at the opposite site in some patients so that additional 9 joints could be examined with the field of view of 18F-FDG PET. Verification and valuation of the PET and scintigraphic image findings were conducted by comparing them with information combined from intraoperative findings, histopathology, and microbiological investigations. Evidence of loosening was correctly determined in 76.4% of cases using 18F-FDG-PET, and in 75% of cases using bone scan. The detection of periprosthetic inflammation using 18F-FDG-PET had a sensitivity of 100% for septic cases and of 45.5% in cases of increased ...Continue Reading

References

Sep 1, 1992·Journal of Computer Assisted Tomography·K WienhardW D Heiss
Nov 18, 2000·Clinical Nuclear Medicine·F De WinterR A Dierckx
Aug 5, 2003·Clinical Orthopaedics and Related Research·Daniëlle NeutHenk J Busscher
Nov 4, 2004·The Journal of Bone and Joint Surgery. American Volume·Olivier P P TemmermanIde C Heyligers
Mar 30, 2005·The Journal of Bone and Joint Surgery. British Volume·P ReinartzU Buell

❮ Previous
Next ❯

Citations

Aug 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Thomas C KweeAbass Alavi
Mar 1, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Filip GemmelChristopher J Palestro
Mar 23, 2013·Expert Opinion on Medical Diagnostics·H John Cooper, Craig J Della Valle
Dec 14, 2007·Clinical Physiology and Functional Imaging·Tarja SoininvaaraHeikki Kröger
May 11, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mariah L WhiteStephen M Broski
Sep 29, 2011·Pain Practice : the Official Journal of World Institute of Pain·Joseph V PergolizziKent H Summers
Jan 28, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Benjamin ZmistowskiEivind Witzo
Jan 28, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Antonia ChenYiRong Zeng
Jul 2, 2011·Annals of the New York Academy of Sciences·Ora Israel, Zohar Keidar
Jan 31, 2012·Infectious Disease Clinics of North America·Emily K ShumanPreeti N Malani
Oct 27, 2017·Annals of Biomedical Engineering·Arash AramiKamiar Aminian
May 23, 2018·AJR. American Journal of Roentgenology·Ali GholamrezanezhadHossein Jadvar
Jul 30, 2014·World Journal of Radiology·Christopher J Palestro
Oct 20, 2018·Acta Orthopaedica·Stefan J GeldermanMarjan Wouthuyzen-Bakker
May 2, 2008·Drugs & Aging·Michael H YoungPreeti N Malani
Jun 27, 2008·Clinical Nuclear Medicine·Julie Louring-Andersen, Ian Law
Nov 12, 2009·Infection·S EspositoUNKNOWN Bone Joint Infections Committee for the Italian Society of Infectious Tropical Diseases (SIMIT)
Apr 24, 2019·AJR. American Journal of Roentgenology·Ila SethiErin E Grady
Feb 8, 2008·The Journal of Bone and Joint Surgery. British Volume·S NagoyaT Yamashita
Apr 20, 2012·Nuclear Medicine Communications·Weiping RenDavid C Markel
Sep 13, 2013·Nuclear Medicine Communications·Stefan HungenbachMatthias C Schmidt
Jul 12, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Thomas Falstie-JensenUNKNOWN ROSA study-group
Dec 21, 2019·International Wound Journal·Jason D HehrIan L Valerio
Dec 2, 2010·The Journal of the American Academy of Orthopaedic Surgeons·Craig Della ValleUNKNOWN American Academy of Orthopaedic Surgeons
Aug 30, 2014·Annals of Nuclear Medicine·Zhengxiao OuyangXianan Li
Dec 29, 2020·The Journal of Bone and Joint Surgery. American Volume·John M PinskiJoseph J Kavolus
Jan 30, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francois JamarAlberto Signore
Jul 9, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher J Palestro
Jul 28, 2021·Biological Chemistry·Sabine SchulzeStefan Rammelt
Oct 6, 2007·Current Opinion in Rheumatology
Oct 26, 2021·Der Orthopäde·Christoph Stotter, Philipp von Roth

❮ Previous
Next ❯

Software Mentioned

ECAT
MathType
Multi Purpose Imaging Tool

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.