The implications of positive peritoneal lavage cytology in potentially resectable pancreatic cancer.

World Journal of Surgery
Ryuji YoshiokaToshiharu Yamaguchi

Abstract

The clinical implications of peritoneal lavage cytology (CY) status in patients with potentially resectable pancreatic cancer have not been established. We retrospectively reviewed clinical data from 254 consecutive patients who underwent macroscopically curative resection for pancreatic cancer from February 2003 to December 2010 in our institution. Correlations between CY status and survival and clinicopathological findings were investigated. Of the 254 patients, 20 were CY+ (7.9 %). There were no significant differences between CY+ and CY- patients in background data (age, sex, the level of preoperative tumor marker, and adjuvant chemotherapy). Patients with positive serosal invasion were more likely to be CY+ than those with negative serosal invasion (P < 0.001) by univariate analysis. The median overall survival of CY+ patients and CY- patients was 23.8 months (95 % CI = 17.6-29.8) and 26.5 months (95 % CI = 20.7-32.3), respectively (P = 0.302). The median recurrence-free survival of CY+ and CY- patients was 8.1 months (95 % CI = 0.0-17.9) and 13.5 months (95 % CI = 11.5-15.5), respectively (P = 0.089). CY+ status without other distant metastasis does not necessarily preclude resection in patients with pancreatic cancer.

References

Jan 1, 1991·American Journal of Surgery·A L Warshaw
Aug 1, 1995·The British Journal of Surgery·C Fernández-del CastilloA L Warshaw
May 23, 1998·Archives of Surgery·M A MakaryC Fernández-del Castillo
Apr 9, 1999·Journal of the American College of Surgeons·N B MerchantM F Brennan
Sep 12, 2000·Journal of Hepato-biliary-pancreatic Surgery·R E JimenezC Fernandez-Del Castillo
Jul 29, 2006·World Journal of Gastroenterology : WJG·Akimasa NakaoShin Takeda
Dec 19, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Cristina R FerronePeter J Allen
May 13, 2008·Journal of the American College of Surgeons·Matthew H G KatzRosa F Hwang
May 15, 2010·American Journal of Surgery·Clancy J Clark, L William Traverso
Sep 30, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·Margaret A TemperoUNKNOWN NCCN Pancreatic Adenocarcinoma
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal

❮ Previous
Next ❯

Citations

Mar 1, 2016·Current Problems in Surgery·Mariam F EskanderJennifer F Tseng
Jul 1, 2014·Surgery Today·Yoshifumi IwagamiHiroaki Nagano
Oct 16, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sohei SatoiA-Hon Kwon
Nov 23, 2019·BMJ Case Reports·Katsutaka MitachiMichiaki Unno
Aug 28, 2019·The British Journal of Surgery·M TanakaT Hackert
Jan 4, 2021·Journal of Cancer Research and Clinical Oncology·Eileen A O'HalloranSanjay S Reddy
Jan 17, 2021·Annals of Surgical Oncology·Mihoko YamadaKatsuhiko Uesaka
Mar 27, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Takuya SakodaShinya Takahashi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.