The implications of stochastic synthesis for the conjugation of functional groups to nanoparticles.

Bioconjugate Chemistry
Douglas G MullenMark M Banaszak Holl

Abstract

Stochastic synthesis of a ligand coupled to a nanoparticle results in a distribution of populations with different numbers of ligands per nanoparticle. This distribution was resolved and quantified using HPLC and is in excellent agreement with the ligand/nanoparticle average measured by 1H NMR, gel permeation chromatography (GPC), and potentiometric titration, and yet significantly more disperse than commonly held perceptions of monodispersity. Two statistical models were employed to confirm that the observed heterogeneity is consistent with theoretical expectations.

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Citations

Aug 5, 2011·Accounts of Chemical Research·Douglas G Mullen, Mark M Banaszak Holl
Mar 24, 2011·Bioconjugate Chemistry·Douglas G MullenMark M Banaszak Holl
Mar 24, 2011·Future Medicinal Chemistry·Carlos F G C GeraldesJoop A Peters
Sep 6, 2012·Therapeutic Delivery·Ryan M PearsonSeungpyo Hong
Dec 7, 2011·European Journal of Medicinal Chemistry·Ming-Hsin LiJames R Baker
Aug 15, 2014·Biomacromolecules·Mallory A van DongenMark M Banaszak Holl
Sep 11, 2010·Biochimica Et Biophysica Acta·Venkataswarup TiriveedhiPeter Butko
Oct 28, 2010·Journal of the American Chemical Society·Ilhem F HakemMichael R Bockstaller
Jun 14, 2014·Bioconjugate Chemistry·Uvaraj UddayasankarUlrich J Krull
Oct 6, 2015·Organic & Biomolecular Chemistry·Eugene Mahon, Mihail Barboiu
Aug 5, 2010·Chemistry : a European Journal·Douglas G MullenMark M Banaszak Holl
Mar 8, 2014·Chemistry : a European Journal·Casey A DoughertyStassi DiMaggio
Jan 15, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jack N WaddellLeonard M Sander
May 17, 2011·Analytical Methods : Advancing Methods and Applications·Ankur M DesaiJames R Baker

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