The importance of cerebrospinal fluid on neural cell proliferation in developing chick cerebral cortex

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
F Mashayekhi, Z Salehi

Abstract

Cerebrospinal fluid (CSF) is mainly produced by the choroid plexuses within the ventricles of the brain. The CSF circulates in a regular manner after the ventricular system and the choroids plexuses have developed, and the foramina in the fourth ventricle have opened to enable it to carry chemical information. CSF flows through the ventricular system passing over all regions of germinal activity. In this study, chick embryos were used to show the importance of CSF on neural cell proliferation in the developing cerebral cortex. The chick embryos were cannulated in situ with a fine capillary tube to drain CSF out of the ventricular system. At the same time, BrdU was administered to the embryos. After surgery the embryos were incubated for another 3 days. Quantitative measurements showed that the thicknesses of the germinal epithelium and cerebral cortex in CSF-drained embryos were less than those in the control group at the same age. The number of cells produced in the germinal epithelium of CSF-drained embryos was decreased when compared with the normal group. This study provides confirmatory evidence that CSF is important for neural cell proliferation and therefore normal development of the cerebral cortex. It is proposed that ...Continue Reading

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Citations

Jul 13, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z Salehi, F Mashayekhi
Jan 26, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F Mashayekhi, Z Salehi
Sep 14, 2010·Trends in Neurosciences·Alexander DityatevMelitta Schachner
Jul 8, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Farhad MashayekhiZivar Salehi
Oct 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Justin D LathiaCharles Ffrench-Constant
May 20, 2015·Developmental Neurobiology·Jessica T ChangHazel Sive
Jul 9, 2021·Fluids and Barriers of the CNS·Vijay KumarJaebong Kim
Oct 17, 2019·Seminars in Cell & Developmental Biology·David BuenoJaleel Miyan

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