The importance of cold and warm cardiac ischemia for survival after heart transplantation

Transplantation
Nicholas R BannerSteering Group of the United Kingdom Cardiothoracic Transplant Audit

Abstract

Ischemia time is a risk factor for mortality after heart transplantation that can be influenced by organizational factors such as transport arrangements and organ allocation. We used the United Kingdom Cardiothoracic Transplant Audit database to analyze the outcome of 1491 first isolated orthotopic adult heart transplants performed between April 1995 and March 2004. Ischemia time and its components (transport time and surgical implant time) were related to 30-day mortality using a multivariable logistic regression model. The median total ischemia time increased from 171 min (interquartile range: 149-198) to 213 min (interquartile range: 181-256) during the study period (P<0.0001). This was due to an increase in transport times that was partly explained by increased organ exchange between centers and also because of an increase in surgical implant times. Thirty-day survival decreased over the study period (91%-84%) with some evidence of a linear trend towards decreasing survival over time (P=0.089). After correcting for other known risk factors, the odds ratio of death within 30 days associated with each 15 min increment in transport time was 1.06 (95% confidence interval: 1.01-1.12) and with each 15 min increment in surgical im...Continue Reading

References

Oct 1, 1978·The Annals of Thoracic Surgery·F T ThomasR R Lower
Nov 1, 1991·The Annals of Thoracic Surgery·G DreyfusA F Carpentier
May 1, 1993·Journal of Cardiac Surgery·M A SarsamA N Rahman
May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D F Del RizzoW J Kostuk
Dec 10, 1999·The Annals of Thoracic Surgery·M S JahaniaR M Mentzer
Apr 17, 2003·The Journal of Thoracic and Cardiovascular Surgery·J K KirklinC White-Williams
Mar 20, 1959·The Journal of General Physiology·G J FUHRMAN, F A FUHRMAN
Dec 11, 2003·The Journal of Thoracic and Cardiovascular Surgery·Jeffrey A MorganNiloo M Edwards
Jun 29, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fotios A MitropoulosHillel Laks
Aug 8, 2006·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David O TaylorUNKNOWN International Society for Heart and Lung Transplantation

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Citations

Apr 16, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Helen L ThomasUNKNOWN Steering Group of the UK Cardiothoracic Transplant Audit
Apr 8, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Feng Hua Yang, W Glen Pyle
Aug 28, 2014·Current Opinion in Organ Transplantation·William M BaldwinRobert L Fairchild
Dec 2, 2014·Current Transplantation Reports·Charles A Su, Robert L Fairchild
Jul 12, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Evan P Kransdorf, Josef Stehlik
Dec 3, 2014·The Annals of Thoracic Surgery·Diana García SáezAndre R Simon
Jul 16, 2010·Wiener klinische Wochenschrift·Daniel HöferUNKNOWN Arbeitskreis "Herztransplantation" der Österreichischen Gesellschaft für Kardiologie
Jun 28, 2012·International Anesthesiology Clinics·Kathirvel Subramaniam
Apr 12, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Warren RodriguesKate L Brown
Aug 21, 2013·Transplantation Proceedings·W YeenC Caldeira
Jun 6, 2012·Transplantation Proceedings·S F MarascoG A Lee
Jul 26, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·David G JonesTom Wong
Jun 17, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mackenzie A FordTajinder P Singh
Jul 2, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Simo O SyrjäläKarl B Lemström
Feb 8, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C A SuR L Fairchild
Jun 13, 2014·Pediatric Transplantation·Joshua D SparksCharles E Canter
May 24, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Simon MesserSteven Tsui
Mar 6, 2015·Transplantation·Vamsidhar B DronavalliNicholas R Banner
Jul 16, 2015·Medical Science Monitor Basic Research·Javid FatullayevMohamed Zeriouh
Jul 24, 2010·Journal of the American College of Cardiology·Vamsidhar B DronavalliRobert S Bonser
May 6, 2015·Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual·David C Mauchley, Max B Mitchell
Jul 14, 2010·The Journal of Thoracic and Cardiovascular Surgery·Phil BothaJohn H Dark
Apr 26, 2016·Transplantation Proceedings·L MantecchiniA Nanni Costa
May 6, 2015·PloS One·Luca Salvatore De SantoCristiano Amarelli
Nov 5, 2011·Seminars in Cardiothoracic and Vascular Anesthesia·Bryan AhlgrenTamas Seres
Dec 1, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Yasuhiro ShudoY Joseph Woo
Mar 4, 2010·Interactive Cardiovascular and Thoracic Surgery·Bartosz RylskiFriedhelm Beyersdorf
Feb 23, 2018·JCI Insight·Hidetoshi TsudaRobert L Fairchild
Jan 26, 2010·Transplantation·Phil BothaJohn H Dark
Mar 29, 2019·Interactive Cardiovascular and Thoracic Surgery·Yuki NakamuraYoshiki Sawa
Apr 26, 2019·Heart Failure Reviews·Sanjeet Singh Avtaar SinghNawwar Al-Attar
Jun 15, 2020·Pediatric Transplantation·Nathanya Baez HernandezRyan J Butts
May 15, 2018·Transplantation·Sanjeet Singh Avtaar SinghNawwar Al-Attar
Apr 26, 2012·Transplantation·Helen L ThomasUNKNOWN Steering Group of the UK Cardiothoracic Transplant Audit
Jan 26, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ioannis DimarakisRajamiyer Venkateswaran
Aug 17, 2018·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Ioannis Dimarakis, Rajamiyer Venkateswaran
Nov 7, 2019·International Journal of Molecular Sciences·Joan Oliva
Sep 22, 2020·Trends in Molecular Medicine·Kourosh Saeb-ParsyMichael P Murphy
Dec 8, 2020·Journal of Cardiac Surgery·Marie D KuzemchakAshish S Shah

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