The importance of cyclin D1 and Ki67 expression on the biological behavior of pancreatic adenocarcinomas

Pathology, Research and Practice
Banu LebeFunda Obuz

Abstract

The aim of this study was to evaluate the role of cyclin D1 and Ki67 proteins involved in cell-cycle control as a prognostic factor in pancreatic carcinomas. We examined formalin-fixed, paraffin-embedded material from 59 pancreatic adenocarcinomas, for which appropriate clinical and prognostic data were available. The standard streptavidin biotin immunoperoxidase method was used for immunostaining with cyclin D1 and Ki67. The extent of positive nuclear and cytoplasmic cyclin D1 staining was graded semiquantitatively. Ki67 reactivity was quantified and expressed as the percentage of stained nuclei. Staining with cyclin D1 and Ki67 was compared with histopathological prognostic features, and their relation with survival was also tested statistically. Patients whose tumors were cyclin D1-positive showed perineural invasion significantly more frequently than did patients with cyclin D1-negative tumors at the immunohistochemical level. In addition, tumors with lymphatic vessel invasion and without showed a significant difference in terms of cytoplasmic cyclin D1 staining. Ki67 indices were statistically different in stage groups. There was a significant and direct correlation between Ki67 index and nuclear cyclin D1 staining scores....Continue Reading

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Citations

Apr 2, 2008·Cellular and Molecular Neurobiology·Sanja MilenkovićIva Berisavac
Jul 24, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Despoina GeorgiadouGeorge C Zografos
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Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Xiaojie ZhuXiaojie Feng
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Feb 27, 2018·Oral Diseases·P Ramos-GarcíaM Á González-Moles
Mar 10, 2020·Pigment Cell & Melanoma Research·Lucia González-RuizPablo Ramos-García

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