The Importance of Excess Poly(N-isopropylacrylamide) for the Aggregation of Poly(N-isopropylacrylamide)-Coated Gold Nanoparticles

ACS Nano
Samuel T JonesOren A Scherman

Abstract

Thermoresponsive materials are generating significant interest on account of the sharp and tunable temperature deswelling transition of the polymer chain. Such materials have shown promise in drug delivery devices, sensing systems, and self-assembly. Incorporation of nanoparticles (NPs), typically through covalent attachment of the polymer chains to the NP surface, can add additional functionality and tunability to such hybrid materials. The versatility of these thermoresponsive polymer/nanoparticle materials has been shown previously; however, significant and important differences exist in the published literature between virtually identical materials. Here we use poly(N-isopropylacrylamide) (PNIPAm)-AuNPs as a model system to understand the aggregation behavior of thermoresponsive polymer-coated nanoparticles in pure water, made by either grafting-to or grafting-from methods. We show that, contrary to popular belief, the aggregation of PNIPAm-coated AuNPs, and likely other such materials, relies on the size and concentration of unbound "free" PNIPAm in solution. It is this unbound polymer that also leads to an increase in solution turbidity, a characteristic that is typically used to prove nanoparticle aggregation. The size o...Continue Reading

References

Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·J E ChungT Okano
Mar 22, 2001·Advanced Drug Delivery Reviews·J Kost, R Langer
Nov 20, 2003·Journal of the American Chemical Society·Nikhil R Jana, Xiaogang Peng
Mar 5, 2004·Journal of the American Chemical Society·Ming-Qiang ZhuAlexander D Q Li
Jul 26, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Jessica Rodríguez-FernándezLuis M Liz-Marzán
Aug 11, 2006·The Journal of Physical Chemistry. B·J KimlingA Plech
Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
Sep 27, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Bridgette M BudhlallOrlin D Velev
Jan 23, 2010·Nature Materials·Martien A Cohen StuartSergiy Minko
Dec 3, 2010·Nature Chemistry·Rafal KlajnBartosz A Grzybowski
Aug 3, 2011·Chemical Communications : Chem Comm·Francesca MastrottoStefano Salmaso
Apr 10, 2013·ACS Applied Materials & Interfaces·Kenichi NiikuraKuniharu Ijiro
Sep 13, 2013·Journal of the American Chemical Society·Ke ZhangChad A Mirkin
Mar 13, 2014·International Journal of Pharmaceutics·Varsha SundaresanAniket S Wadajkar
Feb 21, 2008·Soft Matter·Sheng DaiKam Chiu Tam

❮ Previous
Next ❯

Citations

Jun 22, 2017·ACS Applied Materials & Interfaces·Chuan-Ling ZhangShu-Hong Yu
Nov 7, 2017·Soft Matter·Anne-Caroline Genix, Julian Oberdisse
Jul 13, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xinxin WangZhike He
Oct 23, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Wongi JangJun-Hyun Kim
Nov 12, 2019·Advanced Materials·Tong BianRafal Klajn
Nov 7, 2019·Physical Chemistry Chemical Physics : PCCP·Sudaraka MallawaarachchiMalin Premaratne
Jul 15, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Beatriz Garcia-PinelConsolación Melguizo
Aug 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Tong ShuMichael J Serpe
May 12, 2020·Journal of Biological Engineering·Hongru LiZhiping Qi
Jan 10, 2017·Gels·M Joan TaylorTarsem S Sahota
Jun 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Marlous KampJeremy J Baumberg
May 6, 2021·Angewandte Chemie·Anna A NikitinaEkaterina V Skorb
Dec 2, 2017·Journal of the American Chemical Society·Michał Sawczyk, Rafal Klajn
Oct 3, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Fengyun LiWeiwei Guo
Mar 4, 2020·ACS Central Science·Wenqi YuHuile Gao
Sep 6, 2017·Journal of the American Chemical Society·Wei-Lin WanHsing-Wen Sung
Jun 14, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Sjören SchweizerhofMartin Möller
May 13, 2019·ACS Biomaterials Science & Engineering·Yulin MoYiguang Wang
Jul 1, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Christian RossnerGerald Kothleitner
Sep 4, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Dana KamzabekGalina V Dubacheva
Sep 4, 2021·Beilstein Journal of Organic Chemistry·Patricia FlemmingPetra Uhlmann
Aug 11, 2020·Journal of Colloid and Interface Science·Marlous KampOren A Scherman
Dec 28, 2021·Journal of the American Chemical Society·Chan-Jin KimFrank Caruso

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic light scattering
surface plasmon resonance
column chromatography

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.