The importance of hippocampal dynamic connectivity in explaining memory function in multiple sclerosis

Brain and Behavior
Q van GeestL Douw

Abstract

Brain dynamics (i.e., variable strength of communication between areas), even at the scale of seconds, are thought to underlie complex human behavior, such as learning and memory. In multiple sclerosis (MS), memory problems occur often and have so far only been related to "stationary" brain measures (e.g., atrophy, lesions, activation and stationary (s) functional connectivity (FC) over an entire functional scanning session). However, dynamics in FC (dFC) between the hippocampus and the (neo)cortex may be another important neurobiological substrate of memory impairment in MS that has not yet been explored. Therefore, we investigated hippocampal dFC during a functional (f) magnetic resonance imaging (MRI) episodic memory task and its relationship with verbal and visuospatial memory performance outside the MR scanner. Thirty-eight MS patients and 29 healthy controls underwent neuropsychological tests to assess memory function. Imaging (1.5T) was obtained during performance of a memory task. We assessed hippocampal volume, functional activation, and sFC (i.e., FC of the hippocampus with the rest of the brain averaged over the entire scan, using an atlas-based approach). Dynamic FC of the hippocampus was calculated using a sliding ...Continue Reading

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Citations

Mar 20, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Alessandro d'AmbrosioMaria A Rocca
Dec 12, 2018·Frontiers in Aging Neuroscience·Gwenda EngelsLinda Douw
Mar 20, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Maria A RoccaMassimo Filippi
Jan 5, 2021·JAMA Neurology·Ermelinda De MeoMaria Pia Amato
Jan 14, 2021·Nature Reviews. Neurology·Declan T ChardUNKNOWN MAGNIMS Study Group
Jan 21, 2021·NeuroImage. Clinical·Floris B TijhuisLinda Douw
Jun 15, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Giulia BommaritoDimitri Van De Ville
Oct 30, 2021·Journal of Neurology·Tom A FuchsRalph H B Benedict

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Software Mentioned

Matlab
SienaX
FIRST
FEAT
SPSS
BrainNet Viewer
Melodic
FSL5 FMRIB Software

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