The importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the tongue

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Ali-Farid SafiMatthias Kreppel

Abstract

Locoregional recurrence plays a key role in treatment failure of patients with squamous cell carcinoma of the tongue. In a large amount of studies lymph node ratio could be demonstrated as a promising parameter to stratify risk of patients with oral cavity cancer. However data on the influence of lymph node ratio on locoregional recurrence of tongue squamous cell carcinoma is very rare. Retrospective chart review of 130 patients with treatment naive squamous cell carcinoma of the tongue. Exclusion criteria were neoadjuvant chemoradiotherapy, perioperative death, N3 disease, unresectable disease, synchronous malignancy, follow up <3 months. Contingency tables and χ2-test were performed to analyze associations between clinicopathological features and recurrence. All statistic were 2-sided and a p-value <0.05 was considered as significant. Multivariate analysis was performed using binary logistic regression analysis. A cut off value of 6% for lymph node ratio was applied. Significant correlations were found between locoregional recurrence and pathologic N-Classification (<0.001), UICC stage (<0.001), perineural invasion (p = 0.025), grading (p = 0.001), number of resected lymph nodes (p = 0.007) and lymph node ratio (p < 0.001). M...Continue Reading

Citations

Jan 10, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Junhai DingSen Yang
Jan 24, 2019·Clinical Oral Investigations·Ali-Farid SafiMatthias Kreppel
Feb 13, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·M C KettererC Becker
May 26, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tong-Chao ZhaoLai-Ping Zhong
Jul 26, 2021·International Journal of Oral and Maxillofacial Surgery·S NseirA Rachmiel

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