PMID: 11923114Mar 30, 2002Paper

The importance of lytic and nonlytic immune responses in viral infections

Trends in Immunology
Dominik WodarzAllan Randrup Thomsen

Abstract

Antiviral immune effector mechanisms can be divided broadly into lytic and nonlytic components. We use mathematical models to investigate the fundamental question of which type of response is required to combat different types of viral infection. According to our model, the relative roles of the two types of component depend on the cytopathicity of the virus relative to its rate of replication. If the viral cytopathicity is low relative to the rate of viral replication, the model predicts that a combination of lytic and nonlytic effector mechanisms is likely to be required to resolve the disease, particularly if the virus replicates at a fast rate. By contrast, if viral cytopathicity is high relative to the replication rate of the virus, then lytic and nonlytic mechanisms can, in principle, resolve the infection independently. We discuss our findings in the context of specific viral infections and use our model to interpret empirical data.

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Citations

Aug 30, 2012·Journal of Mathematical Biology·Yan WangJane M Heffernan
Dec 5, 2002·Trends in Immunology·Debbie van BaarleFrank Miedema
Dec 8, 2004·The Journal of Experimental Medicine·Adrian F OchsenbeinPhilip D Greenberg
Jan 26, 2007·Journal of the Royal Society, Interface·Dominik WodarzPaul Klenerman
Aug 2, 2007·Proceedings. Biological Sciences·Dominik Wodarz, David N Levy
Jul 22, 2009·Genetics·Peiqiu Chen, Eugene I Shakhnovich
Mar 27, 2015·Mathematical Biosciences and Engineering : MBE·Haitao SongShengqiang Liu
Oct 2, 2014·Journal of Pharmacokinetics and Pharmacodynamics·Dominik Wodarz
Mar 6, 2016·Theoretical Biology & Medical Modelling·Jorge Reyes-Silveyra, Armin R Mikler
Sep 29, 2007·Journal of Theoretical Biology·Zhiping Wang, Xianning Liu
Jun 27, 2007·Mathematical Biosciences·Kaifa Wang, Wendi Wang
May 19, 2006·Ecology Letters·Dominik Wodarz
Sep 15, 2004·Trends in Immunology·Arno MüllbacherMarkus Simon
Aug 19, 2015·Mathematical Biosciences and Engineering : MBE·Andrei KorobeinikovVladimir Sobolev
May 29, 2012·Journal of Theoretical Biology·Gang HuangAndrei Korobeinikov
Jun 26, 2014·Journal of Biological Dynamics·Ruili FanYasuhiro Takeuchi
Jun 27, 2014·Journal of Virology·Frederik Graw, Roland R Regoes
Jun 18, 2003·The Journal of General Virology·Dominik Wodarz
Jun 1, 2016·Journal of Physics. Conference Series·Andrei KorobeinikovVladimir Sobolev
Jan 1, 2014·Nonlinear Dynamics·Lin-Fei NieIl Hyo Jung
Mar 25, 2021·Mathematical Biosciences and Engineering : MBE·Ning Bai, Rui Xu
Jul 28, 2021·Journal of the Royal Society, Interface·Maria Rita FumagalliCaterina A M La Porta
Aug 18, 2021·Chaos, Solitons, and Fractals·M Pitchaimani, M Brasanna Devi

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