The importance of microjet vs shock wave formation in sonophoresis

Journal of Controlled Release : Official Journal of the Controlled Release Society
Lior Wolloch, Joseph Kost

Abstract

Low-frequency ultrasound application has been shown to greatly enhance transdermal drug delivery. Skin exposed to ultrasound is affected in a heterogeneous manner, thus mass transport through the stratum corneum occurs mainly through highly permeable localized transport regions (LTRs). Shock waves and microjets generated during inertial cavitations are responsible for the transdermal permeability enhancement. In this study, we evaluated the effect of these two phenomena using direct and indirect methods, and demonstrated that the contribution of microjets to skin permeability enhancement is significantly higher than shock waves.

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Citations

Aug 1, 2013·Ultrasonics·Donghee ParkSeunghun Lee
May 3, 2013·International Journal of Nanomedicine·Ying-Zheng ZhaoShu-Ping Ge
Jan 28, 2014·Advanced Drug Delivery Reviews·Aharon AzaguryJoseph Kost
Jun 17, 2014·Biological & Pharmaceutical Bulletin·Maleenart PetchsangsaiTanasait Ngawhirunpat
May 8, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tin Wui Wong
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ai-Ho LiaoMeng-Yu Yang
Aug 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kyle T RichT Douglas Mast
Dec 30, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aharon AzaguryJoseph Kost
Mar 10, 2012·Progress in Biophysics and Molecular Biology·Farzaneh AhmadiGail ter-Haar
Jan 18, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Baris E PolatDaniel Blankschtein
Nov 27, 2015·Pharmaceutical Development and Technology·Kevin Ita
Dec 30, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tao Han, Diganta Bhusan Das
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Feb 13, 2019·Current Pharmaceutical Design·Saloni DaftardarAmit K Tiwari
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May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammed Ali DheyabMahmood S Jameel
Jun 6, 2021·Biosensors & Bioelectronics·Nur Farrahain Nadia AhmadYew Hoong Wong
Jul 4, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Irene de Jesús Martínez-Segoviano, Adriana Ganem-Rondero
Aug 16, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ding ZhangQing Wang

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