The Importance of Natriuretic Peptides in Cardiometabolic Diseases

Journal of the Endocrine Society
Shravya Vinnakota, Horng H Chen

Abstract

The natriuretic peptide (NP) system is composed of 3 distinct peptides (atrial natriuretic peptide or ANP, B-type natriuretic peptide or BNP, and C-type natriuretic peptide or CNP) and 3 receptors (natriuretic peptide receptor-A or NPR-A or particulate guanynyl cyclase-A natriuretic peptide receptor-B or NPR-B or particulate guanynyl cyclase-B, and natriuretic peptide receptor-C or NPR-C or clearance receptor). ANP and BNP function as defense mechanisms against ventricular stress and the deleterious effects of volume and pressure overload on the heart. Although the role of NPs in cardiovascular homeostasis has been extensively studied and well established, much remains uncertain about the signaling pathways in pathological states like heart failure, a state of impaired natriuretic peptide function. Elevated levels of ANP and BNP in heart failure correlate with disease severity and have a prognostic value. Synthetic ANP and BNP have been studied for their therapeutic role in hypertension and heart failure, and promising trials are under way. In recent years, the expression of ANP and BNP in human adipocytes has come to light. Through their role in promotion of adipocyte browning, lipolysis, lipid oxidation, and modulation of adi...Continue Reading

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Citations

Nov 12, 2020·International Journal of Molecular Sciences·Pamela SenesiIleana Terruzzi
Oct 31, 2020·Biochemical Society Transactions·Ningzheng DongQingyu Wu
Mar 25, 2021·Journal of the American Heart Association·Yayan NiuNingzheng Dong
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May 27, 2021·Scientific Reports·Marie-Pierre DubéJean-Claude Tardif
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Aug 28, 2021·Journal of Clinical Medicine·Filippos TriposkiadisEfstathios Iliodromitis
Oct 8, 2021·The Journal of Clinical Investigation·Sumita MishraDavid A Kass

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