The Importance of Natural Antioxidants in the Treatment of Spinal Cord Injury in Animal Models: An Overview

Oxidative Medicine and Cellular Longevity
Angélica Coyoy-SalgadoCarlos E Orozco-Barrios

Abstract

Patients with spinal cord injury (SCI) face devastating health, social, and financial consequences, as well as their families and caregivers. Reducing the levels of reactive oxygen species (ROS) and oxidative stress are essential strategies for SCI treatment. Some compounds from traditional medicine could be useful to decrease ROS generated after SCI. This review is aimed at highlighting the importance of some natural compounds with antioxidant capacity used in traditional medicine to treat traumatic SCI. An electronic search of published articles describing animal models of SCI treated with natural compounds from traditional medicine was conducted using the following terms: Spinal Cord Injuries (MeSH terms) AND Models, Animal (MeSH terms) AND [Reactive Oxygen Species (MeSH terms) AND/OR Oxidative Stress (MeSH term)] AND Medicine, Traditional (MeSH terms). Articles reported from 2010 to 2018 were included. The results were further screened by title and abstract for studies performed in rats, mice, and nonhuman primates. The effects of these natural compounds are discussed, including their antioxidant, anti-inflammatory, and antiapoptotic properties. Moreover, the antioxidant properties of natural compounds were emphasized since...Continue Reading

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Citations

Jan 5, 2021·Critical Reviews in Food Science and Nutrition·Seyed Zachariah MoradiJianbo Xiao
Mar 23, 2021·Oxidative Medicine and Cellular Longevity·Anna Lucia FedulloIlaria Peluso
Apr 15, 2021·Redox Report : Communications in Free Radical Research·Rachid AkkiMohammed Errami

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