The importance of obtaining conjugate views on renographic evaluation of large hydronephrotic kidneys: an in vitro and ex vivo analysis

The Journal of Urology
João Luiz Pippi SalleAntoine E Khoury

Abstract

It is postulated that significant obstruction leads to decreased ipsilateral renal function. However, maintained or even increased differential renal function is often seen in patients with large hydronephrotic kidneys. The reason for such a phenomenon is unclear. We designed an in vitro and ex vivo experimental model that permits the controlled orientation of thinned renal parenchyma and background activity during gamma camera detection. A 5-step experimental study was designed with balloons or reservoirs containing known amounts of radioisotope. A balloon was incrementally compressed between 2 Plexiglas sheets (step 1). Simultaneous measurement of radio emission was done of 5 glass beakers of varying diameters filled with the same amount of water and (99m)Tc (step 2). A single beaker containing diluted (99m)Tc was interfaced with air (step 3) or water (step 4) at different distances from the gamma camera. Pig kidneys previously injected with dimercapto-succinic acid were removed and scanned (step 5). One of the kidneys was then progressively sliced, thinning its parenchyma, and sliced and nonsliced kidneys were simultaneously scanned again. Progressively increased counts were detected as the projected surface area of the radi...Continue Reading

References

Jul 1, 1976·Medical Physics·S R ThomasJ G Kereiakes
Feb 1, 1992·British Journal of Urology·P H O'Reilly
Aug 1, 1990·The Journal of Urology·Y L HomsyC Pison
Aug 1, 1990·The Journal of Urology·P G RansleyT M Barratt
Apr 1, 1993·The Journal of Urology·B BlythJ W Duckett
May 3, 2000·BJU International·A A Shokeir, R J Nijman
Jun 12, 2004·Clinical Nuclear Medicine·Jehanzeb KhanDouglas Canning
Oct 21, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Annelies MaenhoutA Piepsz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.