PMID: 11914117Mar 27, 2002Paper

The importance of oxytocin mechanisms in the control of mouse parturition

Reproduction : the Official Journal of the Society for the Study of Fertility
A J DouglasJ A Russell

Abstract

The role of oxytocin in parturition in mice was investigated. Pup birth profiles, blood samples and brains were collected from parturient mice observed under red light conditions in a reversed light:dark photoperiod. Peripheral administration of an oxytocin antagonist in a dose-dependent manner delayed the birth of subsequent pups, indicating that oxytocin is required for a normal pup birth profile. Oxytocin neurones were activated during birth as shown by both increased immediate early gene ( Fos) expression in oxytocin neurones in the supraoptic nucleus and increased plasma oxytocin concentrations during birth. In addition, the nucleus of the tractus solitarius and the olfactory bulbs, sites that process inputs to oxytocin neurones, become activated during parturition. Exposure to stress during parturition halted subsequent deliveries; at this stage plasma oxytocin concentrations were not higher than those of virgin mice, and birth was restored by administration of oxytocin. Administration of beta-adrenergic antagonist (propranolol) also restored stress-delayed birth, whereas administration of ritrodrine (beta-agonist) delayed birth in non-stressed mice, indicating that adrenergic mechanisms contribute to stress-delayed birth...Continue Reading

Citations

Jul 13, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Natalia AtkinsLouis J Guillette
Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Sep 10, 2013·Progress in Neurobiology·Paula J BruntonJonathan J Hirst
Mar 1, 2003·Frontiers in Neuroendocrinology·John A RussellAlison J Douglas
Jul 21, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·B C NephewR S Bridges
Oct 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yuki TakayanagiKatsuhiko Nishimori
Jan 20, 2007·The Journal of Sexual Medicine·Trynke R de JongMarcel D Waldinger
Sep 21, 2007·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Kathleen R BeebeJanice Humphreys
Jun 2, 2009·Journal of Chemical Neuroanatomy·K SemenikenB Dudas
Oct 2, 2007·Theriogenology·M KlarenbeekM A M Taverne
Nov 21, 2015·The Journal of Physiological Sciences : JPS·Haruhiro Higashida
Jul 27, 2005·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Jun 14, 2018·Physiological Reviews·Benjamin Jurek, Inga D Neumann
Apr 7, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Michael HelwigMartin Klingenspor
Oct 8, 2005·Human Reproduction·H DolatshadM H Johnson
Dec 1, 2010·Biomolecular Concepts·Nicole C Tom, Stephen J Assinder
Sep 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rosemary S E BrownDavid R Grattan
Dec 19, 2020·Acta Physiologica·Manasi MalikSarah K England
Apr 28, 2021·Scientific Reports·Masatoshi NaganoHidenori Suzuki

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