The importance of phospholipase A2 in the early induction by crotoxin of biphasic changes in endplate potentials at the frog neuromuscular junction

Toxicon : Official Journal of the International Society on Toxinology
B J Hawgood, I C Smith

Abstract

In Ca2+-Ringer, crotoxin induced a rapid fall in amplitude of endplate potentials followed by a marked secondary rise but, in Ca2+-free, Sr2+-EGTA Ringer, crotoxin failed to elicit either response. In Ca2+-washout experiments, the onset of giant miniature endplate potentials indicated that binding of crotoxin occurred in Sr2+-EGTA Ringer. Facilitation of endplate potential amplitude due to a closely spaced twin impulse was increased to 162% of control near the peak of the crotoxin-induced secondary phase. These findings are consistent with the phospholipase A2 subunit acting specifically at the active zone.

References

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Citations

Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·L Rodrigues-SimioniI C Smith
Jan 30, 2010·Toxicon : Official Journal of the International Society on Toxinology·Sandra C SampaioYara Cury
May 26, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·L A Ponce-SotoL Rodrigues-Simioni
Apr 2, 2013·Toxicon : Official Journal of the International Society on Toxinology·Rafael Stuani FlorianoLéa Rodrigues-Simioni
May 10, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Eiji YamamotoMotoyuki Ashikari
Oct 3, 2018·Advanced Pharmaceutical Bulletin·Sandro Rostelato-FerreiraThomaz Augusto Alves Rocha-E-Silva
Jan 3, 2021·Toxicon : Official Journal of the International Society on Toxinology·Êmylle Karoline Ramos PintoWalter Luís Garrido Cavalcante

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