The Importance of Signal Strength in Quantitative Assessment of Retinal Vessel Density Using Optical Coherence Tomography Angiography

Scientific Reports
Hyung Bin LimJung Yeul Kim

Abstract

The quality of the scan image is important in microvascular circulation analysis using optical coherence tomography (OCTA). We aimed to investigate the effect of signal strength (SS) on OCTA metrics and minimum SS level that could be considered optimal. Macular 6 × 6 mm angiography images were acquired, and all subjects were divided into four groups according to the SS (SS 7, SS 8, SS 9, and SS 10) of the OCTA image. Vessel density (VD), perfusion density (PD), and foveal avascular zone (FAZ) metrics of the superficial capillary plexus were compared. In total, 446 eyes from young healthy subjects were included. As the SS increased from 7 to 10, the VD and PD of the total area, and the FAZ area increased significantly (all, p < 0.001), but there were no significant difference between SS 9 and SS 10 in all metrics. Correlation analysis between the SS and each parameter showed a high correlation coefficient (VD, r = 0.668; PD, r = 0.671; FAZ area, r = 0.570; all, p < 0.001). The measurements of VD, PD, and FAZ using OCTA varied significantly with the SS, and at least 9 of SS is recommended. The physician should be careful in the analyses of OCTA measurements showing different values of the SS.

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Citations

Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Nov 11, 2019·Clinical & Experimental Ophthalmology·Noha AliFred K Chen
Dec 18, 2019·Journal of Current Ophthalmology·Mojtaba AbrishamiSamira Hassanzadeh
Jan 10, 2020·Investigative Ophthalmology & Visual Science·Andrew J NelsonUNKNOWN African American Eye Disease Study Group
Dec 11, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Viktoria C BrücherMaged Alnawaiseh
Aug 23, 2020·Journal of Clinical Medicine·Elisabetta PilottoEdoardo Midena
Aug 13, 2020·Journal of Clinical Medicine·M Hafi KhanAlex Gentle
Nov 30, 2020·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Mojtaba AbrishamiDavid Sarraf
Sep 7, 2020·American Journal of Ophthalmology·Zhongdi ChuRuikang K Wang
Mar 16, 2021·Frontiers in Aging Neuroscience·William Robert KwapongBo Wu
Jul 19, 2020·American Journal of Ophthalmology·Jesse J JungQuan V Hoang
May 19, 2021·Translational Vision Science & Technology·Brandon J LujanUNKNOWN DRCR Retina Network
Aug 3, 2021·Eye and Brain·Steven M SilversteinRajeev S Ramchandran
Aug 14, 2021·Clinical & Experimental Ophthalmology·Danny Siu-Chun NgTimothy Y Y Lai

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Software Mentioned

AngioPlex
Cirrus OCTA
SPSS
OCTA

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