The importance of the airway microvasculature in asthma

Current Opinion in Allergy and Clinical Immunology
John W Wilson, Su Hii

Abstract

The microvasculature in asthma has been known to contribute to airway-wall thickening and oedema from early post-mortem series. Current concepts of airway inflammation in asthma highlight the importance of the role of the Th2 lymphocyte in the atopic response to aeroallergens, the importance of mast-cell mediators in airway remodelling, potential actions of the vascular response in determining airway thickness and mechanisms of angiogenesis involving endogenous as well as homing progenitor cells with angioblastic potential. The development of animal models of asthmatic airway inflammation and remodelling have given new insight into mechanisms of angiogenesis in asthma. The central role of vascular endothelial growth factor in angiogenesis, vessel leakage and vascular homeostasis is now recognized. A more recent finding is the influence of this factor in enhancing the Th2 response in airway inflammation. The ability of bone marrow-derived angioblasts to migrate to sites of inflammation and contribute to angiogenesis indicates a pivotal role of stem cells in this process. These findings now provide logical links between the inflammatory response, stem-cell mobilization, angiogenesis and airflow obstruction in the remodelled airwa...Continue Reading

References

Mar 1, 1977·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·D Silva
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Jan 1, 1989·The American Review of Respiratory Disease·A L JamesJ C Hogg
Nov 1, 1993·The American Review of Respiratory Disease·K KuwanoJ C Hogg
Sep 1, 1993·The American Review of Respiratory Disease·J W WilsonM C Pain
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·P B BoltonD M McDonald
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·X Li, J W Wilson
Oct 20, 1998·The American Journal of Pathology·G ThurstonD M McDonald
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·R E NockerJ S van der Zee
Dec 23, 1999·Current Opinion in Pulmonary Medicine·J V FahyH A Boushey
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J BousquetA M Vignola
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·S A McColleyS E Crawford
Jul 8, 2000·The European Respiratory Journal·B VrugtR Aalbers
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Nov 18, 2000·The Journal of Allergy and Clinical Immunology·J A DenburgP M O'Byrne
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·M HoshinoQ A Hamid
Jun 9, 2001·The Journal of Allergy and Clinical Immunology·Y C Lee, H K Lee
Jul 4, 2001·American Journal of Respiratory and Critical Care Medicine·B E OrsidaE H Walters
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·S J WilsonS T Holgate
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·D M McDonald
Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith
Sep 3, 2002·Pediatric Pulmonology·Jane C DaviesEric W F W Alton
Sep 5, 2002·Circulation·David SimperNoel M Caplice
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Donald N R PaynePeter K Jeffery
Feb 4, 2003·Current Allergy and Asthma Reports·John W Wilson, Tom Kotsimbos
May 17, 2003·The Journal of Infectious Diseases·Howard DonningerPhilip G Bardin
Jul 5, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Cecile J FavreDonald M McDonald
Jan 1, 1960·Journal of Clinical Pathology·M S DUNNILL
Oct 11, 2003·Urology·Toshiaki KinouchiKatsuhito Takahashi
Oct 28, 2003·The American Journal of Pathology·Peter BalukDonald M McDonald
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simona RussoGiovanni Camussi
Nov 17, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RibattiA Vacca
Jun 25, 2005·American Journal of Respiratory and Critical Care Medicine·Nicola SolicJanis K Shute
Sep 21, 2005·Circulation·Rohit KhuranaIan C Zachary

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Citations

Oct 26, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nir HirshorenRon Eliashar
Jun 24, 2009·Immunology and Cell Biology·Norbert F Voelkel, Sarah Spiegel
Jun 17, 2008·American Journal of Respiratory and Critical Care Medicine·David E SimcockStuart J Hirst
Mar 22, 2008·American Journal of Respiratory and Critical Care Medicine·Davina C M SimoesAndreas Papapetropoulos
Jul 2, 2011·American Journal of Respiratory and Critical Care Medicine·Haruki ImaokaRoma Sehmi
Oct 6, 2010·Respiratory Research·Andrea ZaniniDario Olivieri
Oct 27, 2006·Proceedings of the American Thoracic Society·Scott H Randell
Nov 5, 2011·Proceedings of the American Thoracic Society·Donald M McDonaldPeter Baluk
Jun 28, 2012·Experimental Lung Research·Joanne Van der VeldenKenneth Snibson
Apr 7, 2007·The Journal of Allergy and Clinical Immunology·Steffen KunzmannChristian P Speer
May 7, 2009·Annals of the New York Academy of Sciences·Mimi L K TangSimon G Royce
Jun 15, 2007·The Journal of Allergy and Clinical Immunology·Andrea ZaniniDario Olivieri
Oct 16, 2014·Pulmonary Pharmacology & Therapeutics·Louise M HarknessAnna-Karin Larsson-Callerfelt
Oct 19, 2010·The American Journal of Pathology·Sebastien P TabruynDonald M McDonald
Jan 22, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Hideyuki YamamotoShigeharu Fujieda
Jul 23, 2016·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Brittany M SalterRoma Sehmi
Jul 27, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H YukselC Kirmaz
Feb 10, 2020·The Journal of Allergy and Clinical Immunology·Asawari KordeShervin S Takyar

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