PMID: 9448899Aug 1, 1997Paper

The importance of the autonomic nervous system in health and disease

Australian and New Zealand Journal of Medicine
P Sleight

Abstract

Baroreceptor control of the circulation is now generally thought to be concerned only with short term buffering of changes in arterial pressure, rather than with long term setting of pressure levels. This paper reviews evidence to the contrary, which suggests that impairment of the baroreflex, either by local changes in the carotid sinus or by environmental or genetic influences working through cortical modulation of the reflex gain, may have an important influence on long term arterial pressure. Further interest in the baroreflex has been revived by the demonstration in several large studies that autonomic control, measured either by baroreflex sensitivity (BRS) or heart rate variability (HRV), is a powerful independent prognostic factor, which adds to other clinical measures of risk stratification in patients with left ventricular damage, or who have survived a myocardial infarction. The inter-relationships are complex, poorly understood, and subject to many confounding factors. Nevertheless, BRS and HRV are promising techniques. Further understanding holds out the hope of new therapeutic approaches to these patients.

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References

Oct 22, 1979·The American Journal of Cardiology·P Sleight
Jul 15, 1978·The Medical Journal of Australia·M M WolfJ G Sloman
Mar 1, 1992·The Journal of Physiology·B CasadeiP Sleight
Feb 1, 1992·Circulation·R J ParmerR A Stone
Oct 1, 1971·Circulation Research·B GribbinR Peto
Jun 1, 1982·Clinical Science·H A Struyker-BoudierH Van Essen
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·J V Jones, J S Floras
Mar 1, 1956·Circulation Research·J W MCCUBBINI H PAGE

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Citations

Jan 25, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jerica MaverRok Accetto
Jun 6, 2006·Applied Psychophysiology and Biofeedback·Gustavo A Reyes del PasoM Isabel González
Apr 2, 2003·Neuroscience and Biobehavioral Reviews·Angela J Grippo, Alan Kim Johnson
Apr 28, 2000·Journal of the Autonomic Nervous System·T M Saleh, B J Connell
Feb 19, 2002·Molecular and Cellular Endocrinology·Tarek M SalehAndrea Chisholm
Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·T M SalehB J Connell
Apr 13, 2004·Journal of Hypertension·Xia TaoDing-Feng Su
Aug 7, 2001·Journal of Cardiovascular Pharmacology·Z Z ShanD F Su
Dec 12, 2003·Journal of Cardiovascular Pharmacology·Wuliya Yi-MingDing-Feng Su
Aug 19, 2007·Journal of Cardiovascular Pharmacology·Ke-Yong ShiDing-Feng Su
Jul 13, 2012·Journal of Hypertension·Peter Sleight
May 16, 2008·Psychosomatic Medicine·Angela J GrippoAlan Kim Johnson
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Di-Song WangDing-Feng Su
Oct 20, 2006·Acta Pharmacologica Sinica·Xiao-fei ZhangDing-feng Su
Aug 21, 2008·Anesthesia and Analgesia·Ok Yung ChungAndre Diedrich
Jul 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·He-Hui XieDing-Feng Su
Mar 20, 2013·Physiology & Behavior·Vincent GroteMaximilian Moser
Oct 15, 2009·Autonomic Neuroscience : Basic & Clinical·Joanne L HarrisonJacqueline K Phillips
Jun 8, 2007·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·S DuschekG A Reyes Del Paso
Jan 29, 2013·Psychophysiology·Stefan DuschekGustavo A Reyes del Paso
Jul 5, 2012·Cardiology Research and Practice·Teba AlnimaAbraham A Kroon
Feb 23, 2011·Journal of Pharmacological and Toxicological Methods·L J Shiry, R L Hamlin
Jul 24, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J Andrew Armour
Sep 15, 2007·The Journal of Physiological Sciences : JPS·Stefan Duschek, Gustavo A Reyes del Paso
Apr 2, 2009·Expert Opinion on Therapeutic Targets·Michael DoumasVasilios Papademetriou
Feb 24, 2001·Journal of Hypertension·C J Dickinson
Oct 31, 2013·Physiological Measurement·Jukka A LipponenTiina M Laitinen
Sep 22, 2009·Expert Review of Cardiovascular Therapy·Giuseppe MaranoMarianna Mazza
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deborah A Scheuer, Andrea G Bechtold
Jul 16, 2014·Expert Review of Cardiovascular Therapy·Teba AlnimaPeter W de Leeuw
Apr 24, 2015·Physiological Reports·Michelle Catherine MannSofia B Ahmed

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