The importance of the effect of underlying disease on rejection outcomes following orthotopic liver transplantation

Transplantation
G A BerlakovichR Steininger

Abstract

Despite major advances in immunopharmacology, virtually all patients receive the same center-specific immunosuppressive regimen following orthotopic liver transplantation (OLT). The present analysis was performed on the hypothesis that the original disease representing the indication for OLT leads to a different initial immunological situation of the patient. The type of original disease might therefore be a predisposing factor for acute rejection episodes and influence graft and patient survival. From January 1988 to July 1994, 34 patients received OLT at our institution for end-stage primary biliary cirrhosis (group 1) and 66 patients for end-stage alcoholic cirrhosis (group 2). Overall survivals at 1 and 5 years in group 1 versus group 2 were 67% versus 80% and 50% versus 68%, respectively (P<0.04). Retransplantation was performed in 21% of patients from group 1 and in 6% from group 2. The estimated risk for freedom from acute rejection amounts to 38% in group 1 compared with 59% in group 2 (P<0.02). Multivariate regression analysis of potential risk factors identified only the underlying disease as independent predictor. Analysis of cumulative rates of clinically relevant rejection episodes stratified by group revealed 0.29...Continue Reading

References

Nov 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerR A Krom
Jan 31, 1992·Deutsche medizinische Wochenschrift·S Hauschild, W L Gross
Jun 29, 1989·The New England Journal of Medicine·B H MarkusT E Starzl
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E R DicksonA Langworthy
Jan 1, 1988·Annals of Surgery·J W MarshT E Starzl
Jan 1, 1986·Advances in Immunology·R H Schwartz
Jan 1, 1987·The American Journal of Surgical Pathology·D C SnoverN L Ascher
Jan 1, 1987·Transplantation·J D PerkinsR A Krom
Dec 1, 1985·Journal of Clinical Pathology·S G HubscherP McMaster
Oct 1, 1982·Transplantation·G W Butcher, J C Howard

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Citations

Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerK M Detre
Sep 9, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R H WiesnerR A Krom
Nov 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A J BathgateP C Hayes
Apr 18, 2002·Transplantation Proceedings·D Rodríguez RomanoE Moreno González
Sep 29, 1999·Transplantation Proceedings·D R RomanoE Moreno
Mar 13, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J R JonssonE E Powell
Mar 13, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N Gómez-ManeroJ Prieto
Jan 11, 2014·World Journal of Gastroenterology : WJG·Paula IruzubietaEmilio Fábrega
Oct 3, 2013·Journal of Hepatology·Marco Carbone, James M Neuberger
Oct 15, 2005·Transplant Immunology·L A MarínM R Alvarez-López
Jul 8, 2009·Journal of Clinical Gastroenterology·Maurizio BiselliUNKNOWN Bologna Liver Transplantation Group
Feb 4, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michiel C WarléHugo W Tilanus
Feb 5, 2008·Clinics in Liver Disease·A Corbani, A K Burroughs
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Josh LevitskyHelen S Te
Apr 19, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Saad F JazrawiHugo R Rosen
Jul 22, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Benoit BlanchetAnne Hulin
Mar 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S DharancyF R Pruvot
Mar 9, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Thomas SolimanGabriela A Berlakovich
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A J BathgateK J Simpson
Jan 8, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Caroline C JadlowiecTimucin Taner
Mar 31, 1998·The British Journal of Psychiatry : the Journal of Mental Science·L Howard, T Fahy
Oct 29, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·L R Fisher, K S Henley
Oct 27, 2015·World Journal of Gastroenterology : WJG·José Ursic-BedoyaGeorges-Philippe Pageaux
Dec 14, 2016·Alimentary Pharmacology & Therapeutics·A J Montano-LozaA L Mason
Sep 30, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·David ChoiCostica Aloman
Jun 17, 2020·Clinics and Research in Hepatology and Gastroenterology·Guillaume LassaillySébastien Dharancy

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