PMID: 8960133Dec 2, 1996Paper

The importance of the ERCC1/ERCC4[XPF] complex for hypoxic-cell radioresistance does not appear to derive from its participation in the nucleotide excision repair pathway

Mutation Research
D Murray, E Rosenberg

Abstract

The repair-deficient mutant rodent cell lines UV20 and UV41, which are defective in the ERCC1/ERCC4[XPF]-mediated 5'-endonuclease activity, are unusually sensitive to gamma-irradiation under hypoxic (but not oxic) conditions. Because this 5'-endonuclease appears to be involved in two distinct (but overlapping) DNA-repair pathways-the nucleotide excision repair pathway and the recombination-dependent pathway for the removal of DNA interstrand cross-links-it is unclear which of these defective activities is responsible for the hypoxic radiosensitivity of UV20 and UV41 cells. Accordingly, we have extended these measurements to the UV5 and UV24 lines which carry mutations in the ERCC2[XPD] and ERCC3[XPB] genes, respectively; both of these genes encode DNA helicases. These two mutants display a sensitivity to ultraviolet light that is similar to that of UV20 and UV41 cells, reflecting their defect in the incision step of the nucleotide excision repair pathway. However, neither UV5 nor UV24 cells are especially cross-sensitive to agents that produce DNA interstrand cross-links, suggesting that the ERCC2 and ERCC3 activities are not crucial for the repair of these lesions. We show that neither UV5 nor UV24 cells exhibit the unusual hy...Continue Reading

References

Aug 16, 1977·Biochimica Et Biophysica Acta·A J Fornace, J B Little
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·L H ThompsonD A Glaser
May 1, 1980·Somatic Cell Genetics·L H ThompsonK Brookman
Sep 29, 1995·The Journal of Biological Chemistry·C H ParkA Sancar
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·L H ThompsonM J Siciliano
Apr 5, 1996·The Journal of Biological Chemistry·D MuA Sancar
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·B S AnderssonD Murray

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Citations

Apr 26, 2005·Cancer Treatment Reviews·D M KweekelH-J Guchelaar
Oct 2, 2001·Pharmacology & Therapeutics·M LeszczynieckaP B Fisher
Oct 7, 2003·American Journal of Clinical Oncology·David MurrayM Joan Allalunis-Turner
Mar 2, 2011·Current Opinion in Oncology·Mariana Ba FerreiraEzra Ew Cohen
Apr 15, 2011·Annals of Surgery·Jang-Ming LeeYung-Chie Lee
Sep 10, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Carolin M Grimminger, Peter V Danenberg
Sep 27, 2012·Journal of Cancer Research and Clinical Oncology·Vesna BišofSlavko Gašparov
Mar 5, 2016·Cell Cycle·María José de Miguel-LukenAmancio Carnero
Jun 16, 2015·Gene·Mandira ManandharRichard D Wood
Sep 25, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hyun Woo LeeHo-Yeong Lim
May 4, 2006·Radiation Research·Kurt HaferRobert H Schiestl
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L HampsonI N Hampson
Oct 18, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nan MeiMichael Weinfeld
Jul 15, 2015·The International Journal of Biological Markers·Ariel O ZwengerBernardo A Leone
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ranee MehraBarbara Burtness
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ute Warnecke-EberzPaul M Schneider

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