The importance of the lepidic component as a prognostic factor in stage I pulmonary adenocarcinoma

World Journal of Surgical Oncology
Youngkyu MoonJae Kil Park

Abstract

Stage I pulmonary adenocarcinoma (PA) can offer an unfavorable prognosis. The aim of this study was to classify the prognosis of stage I PA on the basis of the lepidic component and to confirm whether the lepidic component can be used as a criterion for predicting the prognosis of stage I PA. We conducted a retrospective study of patients who underwent curative surgery for stage I and IIA PA. Stage I disease was divided into three groups on the basis of the lepidic component: group 1, ≤10%; group 2, >10 to 50%; and group 3, >50%. We compared recurrence-free survival (RFS) rates among groups 1, 2, and 3, and stage IIA disease. We also evaluated risk factors for disease recurrence with multivariate analysis. A total of 224 patients were included in our study; most patients (n=201) had stage I disease. Three-year RFS rates in group 1 (n=73), group 2 (n=75), and group 3 (n=53) were 74.1, 90.4, and 90.0%, respectively. There was a significant difference in RFS between group 1 and group 2 (p=0.009). The 3-year RFS rate in stage IIA disease was 61.4%. There were no significant differences in RFS between group 1 and stage IIA disease (p=0.163). In multivariate analysis, group 1 had the highest risk of recurrence (HR 5.806, p=0.006) in ...Continue Reading

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Dec 19, 2014·World Journal of Surgical Oncology·Youngkyu MoonJae Kil Park
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Citations

Oct 19, 2017·World Journal of Surgery·Youngkyu MoonJae Kil Park
Dec 14, 2017·The Korean Journal of Thoracic and Cardiovascular Surgery·Min NamkoongJae Kil Park
Jun 27, 2019·The Korean Journal of Thoracic and Cardiovascular Surgery·Jin Won ShinYoungkyu Moon
Oct 12, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yu OkuboYasushi Yatabe

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