The importance of trifluoromethyl pyridines in crop protection

Pest Management Science
Adam BurrissJürgen Schaetzer

Abstract

The pyridine ring, substituted by a trifluoromethyl substituent has been successfully incorporated into molecules with useful biological properties. During the period 1990 to September 2017, 14 crop protection products bearing a trifluoromethyl pyridine have been commercialized or proposed for an ISO common name, covering fungicides, herbicides, insecticides and nematicides. Chemical processes have been developed to provide trifluoromethyl pyridine intermediates, from non-fluorinated pyridine starting materials, at scale and with affordable costs of goods. These attractive starting materials were readily adopted by research chemists, and elaborated through simple chemical modifications into new active ingredients. In a second approach, substituted trifluoromethyl pyridine rings have been constructed from acyclic, trifluoromethyl starting materials, which again has served to identify new active ingredients. Molecular matched pair analysis reveals subtle, yet important differences in physicochemical and agronomic properties of trifluoromethyl pyridines compared with the phenyl analogues. This review focuses on the past 27 years, seeking to identify reasons behind the success of such research programmes, and inspire the search for...Continue Reading

References

May 5, 2004·Hypertension·Yoshio IwashimaToshio Ogihara
Sep 28, 2007·Journal of Computer-aided Molecular Design·John C ShelleyMakoto Uchimaya
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Feb 9, 2017·Journal of Medicinal Chemistry·Lewis D Pennington, Demetri T Moustakas

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Citations

Feb 18, 2021·The Journal of Organic Chemistry·Yuxin DingYongmin Ma

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